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Identification of host-related factors of tumor recurrence and prognosis in rectal cancer after preoperative chemoradiotherapy

Research Project

Project/Area Number 25462051
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionMie University

Principal Investigator

SAIGUSA SUSUMU  三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (10632383)

Co-Investigator(Kenkyū-buntansha) TANAKA KOJI  三重大学, 医学部附属病院, 講師 (10345986)
INOUE YASUHIRO  三重大学, 医学部附属病院, 講師 (20324535)
KUSUNOKI MASATO  三重大学, 医学研究科, 教授 (50192026)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords直腸癌 / 化学放射線療法 / 癌間質 / 再発・予後 / 再発
Outline of Final Research Achievements

The aim of this study is to clarify host-related factors of tumor recurrence and prognosis in rectal cancer patients treated with preoperative chemoradiotherapy (CRT). Stromal CD26 expression, but not cancer CD26 expression, was significantly correlated with tumor recurrence and prognosis. High levels of both infiltrating CD8- and Foxp3-positivecells in cancer stroma were significantly associated with tumor recurrence and poor prognosis. programmed death ligand 1(PD-L1) expression which play a central role in tumor-immune system interactions was significantly associated with tumor recurrence and poor prognosis. Our data reveal important roles of cancer stroma for tumor recurrence and prognosis and suggest that combination of preoperative CRT and immunotherapy such as ant-PD-L1 antibody may contribute to enhancement of therapeutic effect and improvement of prognosis in patients with rectal cancer after preoperative CRT.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Prognostic relevance of stromal CD26 expression in rectal cancer after chemoradiotherapy2016

    • Author(s)
      Susumu Saigusa, Yuji Toiyama, Koji Tanaka, Yasuhiro Inoue, Koichiro Mori, Shozo Ide, Hiroki Imaoka, Mikio Kawamura, Yasuhiko Mohri, Masato Kusunoki
    • Journal Title

      Int J Clin Oncol.

      Volume: 21 Issue: 2 Pages: 350-358

    • DOI

      10.1007/s10147-015-0902-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implication of programed cell death ligand 1 expression with tumor recurrence and prognosis in rectal cancer with neoadjuvant chemoradiotherapy2016

    • Author(s)
      Susumu Saigusa, Yasuhiro Inoue, Yuji Toiyama, Koji Tanaka, Koichiro Mori, Shozo Ide, Hiroki Imaoka, Mikio Kawamura, Yasuhiko Mohri, Masato Kusunoki
    • Journal Title

      Int J Clin Oncol.

      Volume: - Issue: 5 Pages: 946-952

    • DOI

      10.1007/s10147-016-0962-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of M30 expression is correlated with factors reflecting tumor progression in rectal cancer with preoperative chemoradiotherapy2014

    • Author(s)
      Susumu Saigusa, Yasuhiro Inoue, Koji Tanaka, Yoshinaga Okugawa, Yuji Toiyama, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 2 Issue: 1 Pages: 99-104

    • DOI

      10.3892/mco.2013.189

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 直腸癌化学放射線療法後Tumor infiltrating lymphocytesと臨床病理学的因子との関連2015

    • Author(s)
      三枝 晋、問山裕二、田中光司、井上靖浩、森浩一郎、井出正造、今岡裕基、藤川裕之、奥川喜永、廣純一郎、毛利靖彦、楠正人
    • Organizer
      第77回日本臨床外科学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 直腸癌化学放射線療法後Programmed Death Ligand 1発現に関する検討2015

    • Author(s)
      三枝 晋、問山裕二、井上靖浩、田中光司、今岡裕基、井出正造、森浩一郎、野口智史、川村幹雄、藤川裕之、廣純一郎、毛利靖彦、楠 正人
    • Organizer
      第13回日本消化器外科学会大会(第23回日本消化器関連学会週間)
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 食道・直腸癌における術前補助療法によるPrognostic nutritional index変化に関する検討2015

    • Author(s)
      三枝 晋、毛利靖彦、井上靖浩、問山裕二、田中光司、大井正貴、安田裕美、川村幹雄、廣 純一郎、楠 正人
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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