| Project/Area Number |
25462051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
SAIGUSA SUSUMU 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (10632383)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA KOJI 三重大学, 医学部附属病院, 講師 (10345986)
INOUE YASUHIRO 三重大学, 医学部附属病院, 講師 (20324535)
KUSUNOKI MASATO 三重大学, 医学研究科, 教授 (50192026)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 直腸癌 / 化学放射線療法 / 癌間質 / 再発・予後 / 再発 |
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| Outline of Final Research Achievements |
The aim of this study is to clarify host-related factors of tumor recurrence and prognosis in rectal cancer patients treated with preoperative chemoradiotherapy (CRT). Stromal CD26 expression, but not cancer CD26 expression, was significantly correlated with tumor recurrence and prognosis. High levels of both infiltrating CD8- and Foxp3-positivecells in cancer stroma were significantly associated with tumor recurrence and poor prognosis. programmed death ligand 1(PD-L1) expression which play a central role in tumor－immune system interactions was significantly associated with tumor recurrence and poor prognosis. Our data reveal important roles of cancer stroma for tumor recurrence and prognosis and suggest that combination of preoperative CRT and immunotherapy such as ant-PD-L1 antibody may contribute to enhancement of therapeutic effect and improvement of prognosis in patients with rectal cancer after preoperative CRT.
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