Development of cancer treatment harnessing NKT cells with a cross-talk of innate and acquired immunity
| Project/Area Number |
25462056
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUMI Yasuo 神戸大学, 大学院医学研究科, 助教 (00529521)
NAKAMURA Tetsu 神戸大学, 医学部附属病院, 助教 (10403247)
KAMIGAKI Takashi 神戸大学, 大学院医学研究科, 客員教授 (20372641)
KAKEJI Yoshihiro 神戸大学, 大学院医学研究科, 教授 (80284488)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 腫瘍免疫 / NKT細胞 / 大腸癌 |
|---|
| Outline of Final Research Achievements |
The aim of this study is show allogeneic DCG will work stronger than syngeneic DCG in terms of anti-tumor effect in mouse lung metastasis treatment model of NKT cells that act on the innate and acquired immunity system. By introducing tumor antigen into allogeneic or syngeneic DCG, we will elucidate to generate tumor antigen-specific T cells in this system, and moreover, we will create the system to analyze the functions and sequential differentiation of them.
|
Report
(3 results)
Research Products
(6 results)
