| Project/Area Number |
25462059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
Emi Yasunori 九州大学, 医学(系)研究科(研究院), 研究員 (50223673)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Masaru 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (30294937)
KITAO Hiroyuki 九州大学, 医学研究院, 准教授 (30368617)
OKI Eiji 九州大学, 大学病院, 講師 (70380392)
SAEKI Hiroshi 九州大学, 医学研究院, 准教授 (80325448)
安藤 幸滋 九州大学, 大学病院, 助教 (20608864)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大腸癌 / ゲノム不安定性 / 細胞分裂期スピンドルチェックポイント機構 / p53 / MSI / BUBR1 |
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| Outline of Final Research Achievements |
To elucidate the clinical significance of spindle checkpoint protein in colorectal cancer, and to find the new candidate for molecular targeted therapy, we analyzed the expression of the spindle checkpoint proteins in colorectal clinical samples. We investigated the interplay between BUBR1 and p53 and their association with genetic instability in colorectal cancer. In 139 colorectal cases, cases with high BUBR1 expression and TP53 mutation had profound aneuploidy phenotypes and less frequent MSI. On the other hand, high expression of PLK1 was also associated with DNA aneuploidy in clinical gastric cancer specimens. High expression of PLK1 could have detrimental effects in tumors with DNA aneuploidy. These findings indicate that spindle checkpoint proteins might contribute cooperatively to the DNA aneuploidy and the carcinogenesis.
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