The study for molecular mechanism of drug resistance and development of new treatment which aimed at colorectal cancer stem cell.
Project/Area Number |
25462060
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kyushu University |
Principal Investigator |
KIMURA Yasue 九州大学, 医学(系)研究科(研究院), 共同研究員 (70631927)
|
Co-Investigator(Kenkyū-buntansha) |
MORITA Masaru 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 統括診療部長 (30294937)
OKI Eiji 九州大学, 大学病院, 講師 (70380392)
SAEKI Hiroshi 九州大学, 大学病院, 講師 (80325448)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 大腸癌 / 幹細胞 |
Outline of Final Research Achievements |
We recognized LgR5 and EREG in colon cancer tissue by immunohistochemistry. The expression of EREG was strong in advanced colon cancer. The expression of EREG was more strongly in the caser with high therapeutic effect by chemotherapy than the case with low therapeutic effect.
|
Report
(3 results)
Research Products
(14 results)
-
-
-
[Journal Article] The use of a circular side stapling technique in laparoscopic low anterior resection for rectal cancer: experience of 30 serial cases.2015
Author(s)
Oki E, Ando K, Saeki H, Nakashima Y, Kimura Y, Hiyoshi Y, Imamura Y, Ohgaki K, Ito S,Morita M, Ikeda T, Maehara Y
-
Journal Title
Int Surg
Volume: 100
Issue: 6
Pages: 979-83
DOI
Related Report
Peer Reviewed
-
[Journal Article] Endoscopic evaluation of clinical colorectal anastomotic leakage.2015
Author(s)
Ikeda T, Kumashiro R, Taketani K, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Akahoshi T, Hashizume M, Maehara Y.
-
Journal Title
J Surg Res.
Volume: 193
Pages: 126-134
Related Report
Peer Reviewed
-
[Journal Article] A Case of Early Adenosquamous Carcinoma of the Stomach.2013
Author(s)
Kimura Y , Matsuda H, Saeki H, Oki E , Morita M , Sugimachi K,Yamashita Y, Ikegami T, Uchiyama H, Yoshizumi T , Soejima Y, Kawanaka H, Ikeda T, UchiyamaH, Tsutsui S, Fujihara M, Mimori K, Watanabe M, Ishida T, MaeharaY
-
Journal Title
Fukuoka Acta Medica
Volume: 104(9)
Pages: 315-320
NAID
Related Report
Peer Reviewed
-
[Journal Article] Surgical Resection of esophageal cancer synchronously or metachronously associated with head and neck cancer2013
Author(s)
Morita M, Kawano H, Otsu H, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Ikeda T, Kusumoto T, Fukushima J, Nakashima T, Maehara Y.
-
Journal Title
Ann Surg Oncol
Volume: 20(7)
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] Significance and accurate of HER2 evaluation as a new biomarker in advanced gastric cancer.2013
Author(s)
Yasue Kimura, Eiji Oki, Hajime Ohtsu, Yasuo Tsuda, Yuta Kasagi, Gen Hidaka, Eiko Zaitsu, Takafumi Yukaya, Hiroyuki Kawano, Koji Ando, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshihiko Maehara
Organizer
10th International Gastric Cancer Congress
Place of Presentation
Italy
Related Report
Invited
-
[Presentation] 大腸癌肝転移切除症例の治療成績の検討2013
Author(s)
財津 瑛子, 河野 浩幸, 笠木 勇太, 津田 康雄, 日高 元, 大津 甫, 安藤 幸滋, 井田 智, 木村 和恵, 佐伯 浩司, 沖 英次, 森田 勝, 調 憲, 楠本 哲也, 前原 喜彦
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
Related Report
Invited
-
-