The study for molecular mechanism of drug resistance and development of new treatment which aimed at colorectal cancer stem cell.

• Project/Area Number: 25462060
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: KIMURA Yasue 九州大学, 医学(系)研究科(研究院), 共同研究員 (70631927)
• Co-Investigator(Kenkyū-buntansha): MORITA Masaru 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 統括診療部長 (30294937) ; OKI Eiji 九州大学, 大学病院, 講師 (70380392) ; SAEKI Hiroshi 九州大学, 大学病院, 講師 (80325448)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 大腸癌 / 幹細胞

Outline of Final Research Achievements

We recognized LgR5 and EREG in colon cancer tissue by immunohistochemistry. The expression of EREG was strong in advanced colon cancer. The expression of EREG was more strongly in the caser with high therapeutic effect by chemotherapy than the case with low therapeutic effect.

Research Products

• [Journal Article] Incidence of Venous Thromboembolism Following Laparoscopic Surgery for Gastrointestinal Cancer: A Single-Center, Prospective Cohort Study. (2016)
  • Author(s): Kimura Y, Oki E, Ando K, Saeki H, Kusumoto T, Maehara Y. Incidence of Venous Thromboembolism Following Laparoscopic Surgery for Gastrointestinal Cancer: A Single-Center, Prospective Cohort Study.
  • Journal Title: World J Surg Volume: ４０ Issue: 2 Pages: 309-14
  • DOI: 10.1007/s00268-015-3234-y
  • Peer Reviewed
• [Journal Article] Loss of Heterozygosity of PTEN (Encoding Phosphate and Tensin Homolog) Associated with Elevated HER2 Expression Is an Adverse Prognostic Indicator in Gastric Cancer. (2015)
  • Author(s): Zaitsu Y, Oki E, Ando K, Ida S, Kimura Y, Saeki H, Morita M, Hirahashi M, Oda Y, Maehara Y
  • Journal Title: Oncology. Volume: 88 Issue: 3 Pages: 189-194
  • DOI: 10.1159/000368984
  • Peer Reviewed / Open Access
• [Journal Article] The use of a circular side stapling technique in laparoscopic low anterior resection for rectal cancer: experience of 30 serial cases. (2015)
  • Author(s): Oki E, Ando K, Saeki H, Nakashima Y, Kimura Y, Hiyoshi Y, Imamura Y, Ohgaki K, Ito S,Morita M, Ikeda T, Maehara Y
  • Journal Title: Int Surg Volume: 100 Issue: 6 Pages: 979-83
  • DOI: 10.9738/intsurg-d-14-00202.1
  • Peer Reviewed
• [Journal Article] Endoscopic evaluation of clinical colorectal anastomotic leakage. (2015)
  • Author(s): Ikeda T, Kumashiro R, Taketani K, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Akahoshi T, Hashizume M, Maehara Y.
  • Journal Title: J Surg Res. Volume: １９３ Pages: 126-134
  • Peer Reviewed
• [Journal Article] A Case of Early Adenosquamous Carcinoma of the Stomach. (2013)
  • Author(s): Kimura Y , Matsuda H, Saeki H, Oki E , Morita M , Sugimachi K,Yamashita Y, Ikegami T, Uchiyama H, Yoshizumi T , Soejima Y, Kawanaka H, Ikeda T, UchiyamaH, Tsutsui S, Fujihara M, Mimori K, Watanabe M, Ishida T, MaeharaY
  • Journal Title: Fukuoka Acta Medica Volume: １０４（９） Pages: 315-320
  • NAID: 120005372097
  • Peer Reviewed
• [Journal Article] Surgical Resection of esophageal cancer synchronously or metachronously associated with head and neck cancer (2013)
  • Author(s): Morita M, Kawano H, Otsu H, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Ikeda T, Kusumoto T, Fukushima J, Nakashima T, Maehara Y.
  • Journal Title: Ann Surg Oncol Volume: ２０（７）
  • Peer Reviewed
• [Journal Article] Newly developed liver-retraction method for laparoscopic gastric surgery using a silicon disc: the Φ-shaped technique (2013)
  • Author(s): Saeki H, Oki E, Kawano H, Ando K, Kimura Y, Morita M, Kusumoto T, Ikeda T, Maehara Y
  • Journal Title: J Am Coll Surg Volume: ２１６（５）
  • Peer Reviewed
• [Presentation] 胃癌肝転移例における原発巣・転移巣でのHER2発現の差異と治療法選択 (2015)
  • Author(s): 木村和恵、楠本哲也、楠元英次、杉山雅彦、太田光彦、堤敬文、坂口善久、池尻公二
  • Organizer: JDDW2015
  • Place of Presentation: 東京
  • Year and Date: 2015-10-08
• [Presentation] 進行胃癌に対する腹腔鏡手術の短期成績 (2015)
  • Author(s): 木村和恵、楠元英次、杉山雅彦、太田光彦、堤敬文、坂口善久、楠本哲也、池尻公二
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: 静岡
  • Year and Date: 2015-07-15
• [Presentation] リンパ節転移部位から見た食道胃接合部癌に対する手術術式の検討 (2015)
  • Author(s): 木村和恵、楠元英次、杉山雅彦、太田光彦、堤敬文、坂口善久、楠本哲也、池尻公二
  • Organizer: 第69回日本食道学会学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-07-02
• [Presentation] Significance and accurate of HER2 evaluation as a new biomarker in advanced gastric cancer. (2013)
  • Author(s): Yasue Kimura, Eiji Oki, Hajime Ohtsu, Yasuo Tsuda, Yuta Kasagi, Gen Hidaka, Eiko Zaitsu, Takafumi Yukaya, Hiroyuki Kawano, Koji Ando, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshihiko Maehara
  • Organizer: 10th International Gastric Cancer Congress
  • Place of Presentation: Italy
  • Invited
• [Presentation] 大腸癌肝転移切除症例の治療成績の検討 (2013)
  • Author(s): 財津 瑛子, 河野 浩幸, 笠木 勇太, 津田 康雄, 日高 元, 大津 甫, 安藤 幸滋, 井田 智, 木村 和恵, 佐伯 浩司, 沖 英次, 森田 勝, 調 憲, 楠本 哲也, 前原 喜彦
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 術式の工夫と合併症防止の試み 腹腔鏡下前方切除術におけるリニアステープラーを用いた新しい吻合法の開発 (2013)
  • Author(s): 沖 英次池田 哲夫, 安藤 幸滋, 井田 智, 木村 和恵, 佐伯 浩司, 森田 勝, 楠本 哲也, 前原 喜彦
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] S-1/docetaxel remains promising as a first line chemotherapy for Japanese patients with advanced gastric cancer compared with the other standard S-1 based regimens. (2013)
  • Author(s): Tetsuya Kusumoto, Koji Ando, Satoshi Ida, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Yoshihiko Maehara
  • Organizer: ASCO
  • Place of Presentation: シカゴ
  • Invited