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DNA methylation profiling to evaluate the susceptibility to cancer

Research Project

Project/Area Number 25462064
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionJichi Medical University

Principal Investigator

Rikiyama Toshiki  自治医科大学, 医学部, 教授 (80343060)

Co-Investigator(Kenkyū-buntansha) SUZUKI Koichi  自治医科大学, 医学部, 講師 (70332369)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords癌のかかりやすさ / DNAメチル化異常 / NAメチル化マイクロアレイ / 潰瘍性大腸炎 / 大腸癌発癌経路 / 遺伝子修飾異常 / 癌易罹患性 / 重複癌 / Satelliteαtranscript / non-cording RNA / セントロメア / 染色体不安定性 / 背景粘膜
Outline of Final Research Achievements

In this study, we explore DNA methylation alterations in non-cancer tissues to evaluate the susceptibility of cancer. Methylation alterations are observed in both cancer and non-cancer tissues, so we elucidate the levels in non-cancer tissues to link with the predisposition of cancer or detection of early cancer. We identified methylation alterations in some genes decreased in cancer tissues, and explore the levels of methylation in these genes in non-cancer tissues. In ulcerative colitis, we showed that methylation alteration in non-cancer tissues could be a useful biomarker for the predisposition of colitic-cancer. Comprehensive analysis of DNA methylation array in colon cancer revealed that methylation alterations underlying colon cancer development are shared between cancer and adenomas.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2013

All Presentation (9 results) Book (2 results)

  • [Presentation] Liquid biopsy leads to a paradigm shift in cancer treatment.2016

    • Author(s)
      Koichi Suzuki, Yuji Takayama, Tsutomu Daito, Kosuke Ichida, Taro Fukui, Yuta Muto, Nao Kakizawa, Yuji Kaneda, Fumiaki Watanabe, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Hiroshi Noda, Hirokazu Kiyozaki, Fumio Konishi, Toshiki Rikiyama
    • Organizer
      Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisico
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] DNA脱メチル化異常をバイオマーカーとする癌易羅患性の評価2015

    • Author(s)
      齊藤正昭、鈴木浩一、染谷崇徳、石岡大輔、市田晃佑、武藤雄太、加藤高晴、渡部文昭、兼田裕司、辻仲k眞康、菊川利奈、宮倉安幸、清﨑浩一、野田弘志、力山敏樹
    • Organizer
      第26回日本消化器癌発生学会総会
    • Place of Presentation
      米子
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] DNA脱メチル化異常を介した染色体不安定性の解明2015

    • Author(s)
      齊藤正昭、鈴木浩一、市田晃佑、福井太郎、髙山裕司、武藤雄太、加藤高晴、力山敏樹
    • Organizer
      第24回癌病態治療研究会
    • Place of Presentation
      栃木
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Detection of satellite alpha transcript in sera, as a surrogate marker for the risk of development of multiple cancers in colorectal cancer patients.2015

    • Author(s)
      Kosuke Ichida, Koichi Suzuki, Yuji Takayama, Yuta Muto, Taro Fukui, Takaharu Kato, Masaaki Saito, Fumiaki Watanabe, Nao Kakizawa, Hirofumi Imoto, Hiroyuki Tanaka, Yuji Kaneda, Yusuke Taniyama, Shingo Tsujinaka, Osamu Takata, Yasuyuki Miyakura, Hiroshi Noda, Hirokazu Kiyozaki, Fumio Konishi, Toshiki Rikiyama
    • Organizer
      American Society of Clinical Oncology
    • Place of Presentation
      chicago
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Emergence of KRAS mutation in detection of circulating tumor DNA during treatments for metastatic gastrointestinal cancer patients.2015

    • Author(s)
      Yuji Takayama, Koichi Suzuki, Tsutomu Daito, Kosuke Ichida, Taro Fukui, Yuta Muto, Nao Kakizawa, Hirofumi Imoto, Yusuke Taniyama, Yuji Kaneda, Hiroyuki Tanaka, Fumiaki Watanabe, Takaharu Kato, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Yasuyuki Miyakura, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
    • Organizer
      American Society of Clinical Oncology
    • Place of Presentation
      chicago
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゲノムワイドな脱メチル化によるsatellite alpha transcripts の増加と大腸癌発癌についての検討2013

    • Author(s)
      加藤高晴、鈴木浩一、神山英範、齊藤正昭、武藤雄太、小西文雄、力山敏樹
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Demethylation in centromeric region promotes chromosomal instability via induction of satellite transcripts2013

    • Author(s)
      Kato T, Suzuki K, Kamiyama H, Muto Y, Saito M, Konishi F, Rikiyama T
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] The accumulation of DNA demethylation in SAT-A in normal gastric tissues with helicobacter pylori infection renders susceptibility to gastric cancer in some individuals.2013

    • Author(s)
      Saito M, Kiyozaki H, Rikiyama T
    • Organizer
      10th International Gastric Cancer Congress
    • Place of Presentation
      Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] Chromosomal instability induced by demethylation alterations2013

    • Author(s)
      Suzuki K, Kato T, Kamiyama H, Muto Y, Saito M, Konishi F, Rikiyama T
    • Organizer
      The 10th Nikko International Symposium
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
  • [Book] 腫瘍性大腸炎のゲノム・エピゲノム解析2015

    • Author(s)
      鈴木浩一、力山敏樹
    • Total Pages
      5
    • Publisher
      医学のあゆみ
    • Related Report
      2015 Annual Research Report
  • [Book] DNAメチル化プロファイルによる膵癌診断膵癌治療up-to-date2015

    • Author(s)
      鈴木浩一、力山敏樹
    • Total Pages
      8
    • Publisher
      医学図書出版株式会社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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