DNA methylation profiling to evaluate the susceptibility to cancer
| Project/Area Number |
25462064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Koichi 自治医科大学, 医学部, 講師 (70332369)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌のかかりやすさ / DNAメチル化異常 / NAメチル化マイクロアレイ / 潰瘍性大腸炎 / 大腸癌発癌経路 / 遺伝子修飾異常 / 癌易罹患性 / 重複癌 / Satelliteαtranscript / non-cording RNA / セントロメア / 染色体不安定性 / 背景粘膜 |
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| Outline of Final Research Achievements |
In this study, we explore DNA methylation alterations in non-cancer tissues to evaluate the susceptibility of cancer. Methylation alterations are observed in both cancer and non-cancer tissues, so we elucidate the levels in non-cancer tissues to link with the predisposition of cancer or detection of early cancer. We identified methylation alterations in some genes decreased in cancer tissues, and explore the levels of methylation in these genes in non-cancer tissues. In ulcerative colitis, we showed that methylation alteration in non-cancer tissues could be a useful biomarker for the predisposition of colitic-cancer. Comprehensive analysis of DNA methylation array in colon cancer revealed that methylation alterations underlying colon cancer development are shared between cancer and adenomas.
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Report
(3 results)
Research Products
(11 results)
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[Presentation] Liquid biopsy leads to a paradigm shift in cancer treatment.2016
Author(s)
Koichi Suzuki, Yuji Takayama, Tsutomu Daito, Kosuke Ichida, Taro Fukui, Yuta Muto, Nao Kakizawa, Yuji Kaneda, Fumiaki Watanabe, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Hiroshi Noda, Hirokazu Kiyozaki, Fumio Konishi, Toshiki Rikiyama
Organizer
Gastrointestinal Cancers Symposium
Place of Presentation
San Francisico
Year and Date
2016-01-21
Related Report
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[Presentation] Detection of satellite alpha transcript in sera, as a surrogate marker for the risk of development of multiple cancers in colorectal cancer patients.2015
Author(s)
Kosuke Ichida, Koichi Suzuki, Yuji Takayama, Yuta Muto, Taro Fukui, Takaharu Kato, Masaaki Saito, Fumiaki Watanabe, Nao Kakizawa, Hirofumi Imoto, Hiroyuki Tanaka, Yuji Kaneda, Yusuke Taniyama, Shingo Tsujinaka, Osamu Takata, Yasuyuki Miyakura, Hiroshi Noda, Hirokazu Kiyozaki, Fumio Konishi, Toshiki Rikiyama
Organizer
American Society of Clinical Oncology
Place of Presentation
chicago
Year and Date
2015-05-29
Related Report
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[Presentation] Emergence of KRAS mutation in detection of circulating tumor DNA during treatments for metastatic gastrointestinal cancer patients.2015
Author(s)
Yuji Takayama, Koichi Suzuki, Tsutomu Daito, Kosuke Ichida, Taro Fukui, Yuta Muto, Nao Kakizawa, Hirofumi Imoto, Yusuke Taniyama, Yuji Kaneda, Hiroyuki Tanaka, Fumiaki Watanabe, Takaharu Kato, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Yasuyuki Miyakura, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
Organizer
American Society of Clinical Oncology
Place of Presentation
chicago
Year and Date
2015-05-29
Related Report
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