| Project/Area Number |
25462066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Masaki Tadahiko 杏林大学, 医学部, 教授 (30238894)
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| Research Collaborator |
Nozaki Eriko 杏林大学, 医学研究科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 結腸癌 / 浸潤先進部 / EMT / マイクロアレイ / 先進部 / ケモカイン / CXCR3 / 癌先進部 |
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| Outline of Final Research Achievements |
Expressions of chmokines, CCL9-10 were increased at invasive front of colon cancer in previous study. We analysed common receptor, CXCR3 to those chemokines.
CXCR3 have two isoforms, CXCR3A and CXCR3B, expression of CXCR3 was overall increased in cancer tissue. The ratio of CXCR3B/CXCR3A was significantly high at invasive front. CXCR3A increased abilities of proliferation, invasion and motility for colorectal cancer cell lines.
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