The impact of surfactant protein d on inflammatory bowel disease
| Project/Area Number |
25462067
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSURUTA Masashi 慶應義塾大学, 医学部, 助教 (00348666)
|
|---|
| Research Collaborator |
YAHAGI Masashi
TAJIMA Yuki
TOYODA Naoyoshi
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | サーファクタントプロテインd / 炎症性腸疾患 / 潰瘍性大腸炎 / ｻｰﾌｧｸﾀﾝﾄﾌﾟﾛﾃｲﾝｄ |
|---|
| Outline of Final Research Achievements |
We focused on surfactant, pulmonary-associated protein D (SFTPD) which encodes surfactant protein D (SP-D) and evaluated the role of SP-D in ulcerative colitis (UC) in this current study. In model mouse with dextran sulfate sodium (DSS) induced colitis, the serum level of SP-D was significantly higher compared with control mouse. In addition, relatively higher level of SP-D protein was observed in mucosa of colon in the mouse with DSS induced colitis mouse. Moreover, the severity of colitis induced by DSS was mitigated in SP-D deficiency mouse compared to wild mouse. Collectively, SP-D would be associated with pathogenesis and progression of UC and could be expected a target for prevention or treatment.
|
Report
(3 results)
Research Products
(1 results)
