| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
With the cap analysis of gene expression (CAGE), we conducted an exhaustive gene expression analysis in carcinoma tissue of colorectal cancer accompanied by metastases. Between the cases with and without liver metastasis or lymph node metastasis, there were differences in genes of which expression were promoted or suppressed. Some gene expressions were enhanced only in cases with liver metastasis or in those of lymph node, specifically. As a novel biomarker, the clinical application of genes identified in this work will enable us to detect earlier and to predict lymph node and liver metastases in colorectal cancer. It should help to promote clinical diagnosis and medical care of the cancer.
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