Development of new chemotherapeutic agents using monoterpenes

• Project/Area Number: 25462069
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Yokohama City University (2015); University of Tsukuba (2013)
• Principal Investigator: MURATA Soichiro 横浜市立大学, 医学部, 准教授 (40436275)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大腸癌 / モノテルペン / 化学療法 / アポトーシス / 1,8-cineole

Outline of Final Research Achievements

Monoterpenes are derived from natural plants and some of them have anti-tumor activity. We evaluated three kinds of monoterpenes, 1,8-cineole, terpinen 4-ol, and linalool, induced apoptosis in human colon cancer cell line HCT116 and RKO. In xenotransplanted SCID mice, these monoterpenes significantly inhibited tumor progression compared to control. Based on these studies, monoterpenes iwould be an effective strategy to treat unresectable colorectal cancer tumor especially 1,8-cineole, terpinen 4-ol, and linalool.

Research Products

• [Journal Article] Antitumor effect of 1, 8-cineole against colon cancer. (2013)
  • Author(s): Murata S, Shiragami R, Kosugi C, Tezuka T, Yamazaki M, Hirano A, Yoshimura Y, Suzuki M, Shuto K, Ohkohchi N, Koda K.
  • Journal Title: Oncol Rep Volume: 30(6) Issue: 6 Pages: 2647-2652
  • DOI: 10.3892/or.2013.2763
  • Peer Reviewed
• [Presentation] 赤ワインに含まれるLinaloolは腫瘍選択的に細胞膜脂質の過酸化を引き起こしアポトーシスを誘導する (2016)
  • Author(s): 岩崎健一、村田聡一郎、大和田洋平、中山健、黒川友博、佐野直樹、田野井智倫、松村英樹、寺崎正彦、伊藤紘、松井裕史、鄭允文、大河内信弘
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: リーガロイヤルホテル大阪（大阪府）
  • Year and Date: 2016-04-14
• [Presentation] アロマオイルによる新規抗癌治療 (2015)
  • Author(s): 中山健、村田聡一郎、岩崎健一、黒川友博、佐野直樹、田野井智倫、野渡剛之、Villareal Myra Orlina、礒田博子、大河内信弘
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Year and Date: 2015-04-16
• [Presentation] 1,8-シネオールはヒト大腸癌細胞の増殖を抑制する (2013)
  • Author(s): 村田聡一郎、白神梨沙、小杉千弘、平野敦史、吉村雪野、山崎将人、首藤潔彦、幸田圭史
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: マリンメッセ福岡（福岡市）
  • Invited
• [Presentation] 1,8-シネオールによるヒト大腸癌細胞のアポトーシス効果の検討 (2013)
  • Author(s): 村田聡一郎、白神梨沙、小杉千弘、平野敦史、吉村雪野、山崎将人、首藤潔彦、幸田圭史
  • Organizer: 第68回日本消化器外科学会総会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎市）
• [Presentation] Specific induction of apoptosis by 1,8-cineole in human colon cancer cells. (2013)
  • Author(s): Soichiro Murata, Keisuke Kohno, Satoshi Inagawa, Tatsuya Oda, Nobuhiro Ohkohchi
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Book] New chemotherapeutic agents: Monoterpenes and fatty acid synthase inhibitors (2016)
  • Author(s): Soichiro Murata
  • Total Pages: 26
  • Publisher: INTECH