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mechanism of liver metastasis focused on the interaction between tumor cells and Kupffer cells

Research Project

Project/Area Number 25462078
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kondo Tadashi  筑波大学, 医学医療系, 教授 (00375495)

Co-Investigator(Kenkyū-buntansha) FUKUNAGA Kiyoshi  筑波大学, 医学医療系, 講師 (20361339)
TAMURA Takafumi  筑波大学, 医学医療系, 講師 (20633192)
Co-Investigator(Renkei-kenkyūsha) OHKOHCHI Nobuhiro  筑波大学, 医学医療系, 教授 (40213673)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝転移 / クッパー細胞 / 肝微小循環 / 大腸癌
Outline of Final Research Achievements

In this study, to clarify the role of Kupffer cells (KCs) in the liver metastasis, we used intravital microscopy (IVM) to analyze the sinusoidal dynamics of both KCs and TCs in colon cancer metastasis to the liver. IVM showed that TCs adhered to KCs from the early time after TC injection. The KCs phagocytosed the TCs, which adhered with the KCs. In addition, we eliminated KCs at different time points before or after injection of tumor cells (TCs). The role of KCs was suppressive especially in the early stage of liver metastasis. It is suggested that KC phagocytosis of TCs in the early stage of liver metastasis strongly suppressed the formation of the liver metastatic nodules thereafter.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Kupffer cells have suppressive function for liver metastasis formation of colon cancer in early stage.2015

    • Author(s)
      松村英樹, 近藤匡, 小川光一, 田村孝史, 福永潔, 大河内信弘.
    • Journal Title

      Organ Biology

      Volume: 22 Issue: 2 Pages: 184-192

    • DOI

      10.11378/organbio.22.184

    • NAID

      130005142916

    • ISSN
      1340-5152, 2188-0204
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血行性肝転移早期におけるKupffer細胞と腫瘍細胞の類洞内動態2015

    • Author(s)
      松村英樹, 近藤匡, 小川光一, 田村孝史, 福永潔, 大河内信弘.
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌の血行性肝転移の初期段階におけるKupffer細胞の役割2013

    • Author(s)
      松村英樹
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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