Analysis of the role hepatic hypertrophy and functional analysis of hepatic stem/progenitor cells after the induction of hypertrophy of the liver

• Project/Area Number: 25462079
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Chiba University
• Principal Investigator: KATO ATSUSHI 千葉大学, 医学(系)研究科(研究院), 講師 (70344984)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI MASARU 千葉大学, 大学院医学研究院, 教授 (70166156) ; KUBOKI SATOSHI 千葉大学, 医学部附属病院, 助教 (50571410) ; OKAMURA DAIKI 千葉大学, 大学院医学研究院, 特任講師 (50375698)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝再生 / 門脈塞栓術 / 胆管炎 / 肝類洞内皮障害 / 肝幹・前駆細胞 / 類洞内皮障害 / 肝幹細胞

Outline of Final Research Achievements

Portal vein embolization (PVE) in patients with elevated bilirubin levels dose not affect in hypertrophy of remnant liver and postoperative outcomes of subsequent major hepatectomy. Therefore, PVE can perform safely and effectively in patients with obstructive jaundice regardless of serum bilirubin concentration. （Hepatogastroenterology. 61: 908-15, 2014）In multivariate analysis, remnant liver volume, serum ALP levels, and serum CRP levels are independent predictive facts for hypertrophy of remnant liver after PVE. These results suggest that acute cholangitis could attenuate hypertrophy of remnant liver. We think about the challenges and future directions of the mechanisms of hypertrophy of remnant liver after PVE by assessing the activation of hepatic stellate cells, function of hepatic stem/progenitor cells.

Research Products

• [Journal Article] Pin1 facilitates NF-κB activation and promotes tumour progression in human hepatocellular carcinoma. (2015)
  • Author(s): Shinoda K, Kuboki S, Shimizu H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Miyazaki M.
  • Journal Title: British journal of Cancer Volume: 113 Issue: 9 Pages: 1323-1331
  • DOI: 10.1038/bjc.2015.272
  • Peer Reviewed
• [Journal Article] Downsizing Chemotherapy for Initially Unresectable Locally Advanced Biliary Tract Cancer Patients Treated with Gemcitabine Plus Cisplatin Combination Therapy Followed by Radical Surgery. (2015)
  • Author(s): Kato A, Shimizu H, Ohtsuka M, Yoshitomi H, Furukawa K, Takayashiki T, Nakadai E, Kishimoto T, Nakatani Y, Yoshidome H, Miyazaki M.
  • Journal Title: Annals of Surgical Oncology Volume: 22 suppl 3 Issue: S3 Pages: 1093-1099
  • DOI: 10.1245/s10434-015-4768-9
  • Peer Reviewed
• [Journal Article] Surgical Strategy for Hilar Cholangiocarcinoma of the Left-Side Predominance: Current Role of Left Trisectionectomy. (2014)
  • Author(s): Hosokawa I, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Miyazaki M.
  • Journal Title: Annals of Surgery Volume: in press
  • Peer Reviewed
• [Journal Article] Surgical resection after downsizing chemotherapy for initially unresectable locally advanced biliary tract cancer: a retrospective single-center study. (2013)
  • Author(s): 加藤 厚
  • Journal Title: Ann Surg Oncol. Volume: 20 Issue: 1 Pages: 318-324
  • DOI: 10.1245/s10434-012-2312-8
  • Peer Reviewed
• [Presentation] 高度血管侵襲を有する切除不能局所進行胆道癌に対するConversion Therapyの有用性 (2015)
  • Author(s): 加藤 厚、清水宏明、大塚将之、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、酒井 望、賀川真吾、宮崎 勝
  • Organizer: 第77回日本臨床外科学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2015-11-26
• [Presentation] Downsizing chemotherapy followed by surgical resection for patients with initially unresectable locally advanced biliary tract cancer (2015)
  • Author(s): Atsushi Kato, Hiroaki Shimizu, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daiki Okamura, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-10-29
• [Presentation] A new multidisciplinary approach for initially unresectable locally advanced biliary tract cancer (2015)
  • Author(s): Atsushi Kato, Hiroaki Shimizu, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daiki Okamura, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
  • Organizer: 第27回日本肝胆膵外科学会・学術集会
  • Place of Presentation: ホテルグランパシフィック（東京都港区）
  • Year and Date: 2015-06-11
• [Presentation] 肝内胆管癌に対する外科切除を中心とした治療戦略. (2015)
  • Author(s): 大塚将之, 清水宏明, 加藤 厚, 吉富秀幸, 古川勝規, 高屋敷 吏, 久保木 知, 高野重紹, 岡村大樹, 鈴木大亮, 酒井 望, 賀川真吾, 宮崎 勝.
  • Organizer: 第27回日本肝胆膵外科学会・学術集会
  • Place of Presentation: ホテルグランパシフィック（東京都港区）
  • Year and Date: 2015-06-11