Exploratory analysis for imaging biomarkers of hepatocellular carcinoma
| Project/Area Number |
25462082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Ban Daisuke 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40376736)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Shinji 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420)
TANABE Minoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50197513)
MIURA Tomoya 東京医科歯科大学, 大学院医歯学総合研究科, 医員 (30618111)
OBA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 医員 (70740257)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肝細胞癌 / EOB-MRI / SLCO1B3 / OATP1B3 |
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| Outline of Final Research Achievements |
On Gd-EOB-DTPA, although hepatocellular carcinoma (HCC) is typically lower intensity lesion in the hepatobiliary phase, cases of highly enhanced HCC (High-HCC) have been reported. This study aimed to reveal the clinicopathological and biological properties of the High-HCC. Patients who underwent curative hepatectomy as the first treatment for HCC were included. We retrospectively performed clinicopathological and global gene expression analyses.
Serum PIVKA-II levels in the High-HCC were lower, and the High-HCC were well-differentiated. Disease-free survival was prolonged in the High-HCC. Global gene expression analysis revealed the upregulated genes included those mediating normal hepatic metabolism. In addition, SLCO1B3 was upregulated in the High-HCC. This was validated by immunohistochemical analysis. We revealed HCC characteristics of hyperintensity in the hepatobiliary phase of EOB-MRI and a relatively low malignant potential.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis.2016
Author(s)
Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M.
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Journal Title
Plos One
Volume: -
Issue: 1
Pages: e0146564-e0146564
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.2016
Author(s)
Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
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Journal Title
Int. J. Oncol.
Volume: 48
Issue: 2
Pages: 657-669
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The difficulty of laparoscopic liver resection.2015
Author(s)
Ban D, Kudo A, Ito H, Mitsunori Y, Matsumura S, Aihara A, Ochiai T, Tanaka S, Tanabe M, Itano O, Kaneko H, Wakabayashi G.
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Journal Title
Updates Surgery.
Volume: 67
Issue: 2
Pages: 123-128
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel Aurora/VEGFR dual kinase inhibitor as treatment for hepatocellular carcinoma.2015
Author(s)
Nakao K, Tanaka S, Miura T, Sato K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M.
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Journal Title
Cancer Science
Volume: 106(8)
Issue: 8
Pages: 1016-1022
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel therapeutic combination targeting sequentially Aurora B and Bcl-xL in hepatocellular carcinoma.2015
Author(s)
Matsunaga H, Tanaka S, Aihara A, Ogawa K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Arii S, Tanabe M.
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Journal Title
Annals of Surgical Oncology
Volume: 22(9)
Issue: 9
Pages: 1016-1022
DOI
Related Report
Peer Reviewed
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