Research Project
Grant-in-Aid for Scientific Research (C)
On Gd-EOB-DTPA, although hepatocellular carcinoma (HCC) is typically lower intensity lesion in the hepatobiliary phase, cases of highly enhanced HCC (High-HCC) have been reported. This study aimed to reveal the clinicopathological and biological properties of the High-HCC. Patients who underwent curative hepatectomy as the first treatment for HCC were included. We retrospectively performed clinicopathological and global gene expression analyses.Serum PIVKA-II levels in the High-HCC were lower, and the High-HCC were well-differentiated. Disease-free survival was prolonged in the High-HCC. Global gene expression analysis revealed the upregulated genes included those mediating normal hepatic metabolism. In addition, SLCO1B3 was upregulated in the High-HCC. This was validated by immunohistochemical analysis. We revealed HCC characteristics of hyperintensity in the hepatobiliary phase of EOB-MRI and a relatively low malignant potential.
All 2016 2015 2014
All Journal Article (8 results) (of which Peer Reviewed: 8 results, Open Access: 3 results) Presentation (17 results)
Plos One
Volume: - Issue: 1 Pages: e0146564-e0146564
10.1371/journal.pone.0146564
Int. J. Oncol.
Volume: 48 Issue: 2 Pages: 657-669
10.3892/ijo.2015.3299
Am J Surg.
Volume: 210 Issue: 3 Pages: 561-569
10.1016/j.amjsurg.2015.03.027
Updates Surgery.
Volume: 67 Issue: 2 Pages: 123-128
10.1007/s13304-015-0302-7
Asian J Endosc Surg.
Volume: 8 Issue: 1 Pages: 11-15
10.1111/ases.12164
Cancer Science
Volume: 106(8) Issue: 8 Pages: 1016-1022
10.1111/cas.12701
Annals of Surgical Oncology
Volume: 22(9) Issue: 9 Pages: 1016-1022
10.1245/s10434-014-4292-3
Am J Surg
Volume: 209 Pages: 199-205
