Effects of free fatty acid on malignant potential of hepatocellular carcinoma derived from fatty liver

Research Project

Project/Area Number	25462085
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	Sakaguchi Takanori 浜松医科大学, 医学部附属病院, 講師 (70313955)
Co-Investigator(Kenkyū-buntansha)	MORITA YOSHIFUMI 浜松医科大学, 医学部・附属病院, 助教 (60464129)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	肝臓外科学 / 消化器外科 / 肝臓外科 / 肝細胞癌 / 脂質代謝 / 脂肪酸
Outline of Final Research Achievements	In this study, we found the following facts: 1) hepatocellular carcinoma (HCC) derived from metabolic syndrome-related fatty liver express high amount of the enzyme Elovl-6. 2) Elovl-6 converts palmitic acid, a strong endoplasmic reticulum stressor, to harmless stearic acid. 3) HCC can survive such stressful condition via high Elovl-6 expression.

Report

(3 results)