Effects of free fatty acid on malignant potential of hepatocellular carcinoma derived from fatty liver
| Project/Area Number |
25462085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA YOSHIFUMI 浜松医科大学, 医学部・附属病院, 助教 (60464129)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肝臓外科学 / 消化器外科 / 肝臓外科 / 肝細胞癌 / 脂質代謝 / 脂肪酸 |
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| Outline of Final Research Achievements |
In this study, we found the following facts: 1) hepatocellular carcinoma (HCC) derived from metabolic syndrome-related fatty liver express high amount of the enzyme Elovl-6. 2) Elovl-6 converts palmitic acid, a strong endoplasmic reticulum stressor, to harmless stearic acid. 3) HCC can survive such stressful condition via high Elovl-6 expression.
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Report
(3 results)
Research Products
(5 results)
