| Project/Area Number |
25462086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
Sugawara Gen 名古屋大学, 医学部附属病院, 病院講師 (00402587)
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| Co-Investigator(Kenkyū-buntansha) |
NAGINO MASATO 名古屋大学, 医学系研究科, 教授 (20237564)
YOKOYAMA YUKIHIRO 名古屋大学, 医学部附属病院, 講師 (80378091)
KOKURYO TOSHIO 名古屋大学, 医学系研究科, 特任講師 (60378023)
ITATSU KEITA 名古屋大学, 医学系研究科, 寄附講座助教 (90534842)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肝虚血再灌流障害 / 分枝鎖アミノ酸 / 肝虚血再潅流障害 |
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| Outline of Final Research Achievements |
BCAAs (branched-chain amino acids) suppress inflammatory factors, such as IL-6 (interleukin-6), TNFα (tumor necrosis factor alpha), ET1 (endothelin 1), ICAM (intercellular adhesion molecule) and VCAM (vascular cell adhesion molecule), in liver tissue of a model of ischemia / re-perfusion (I/R) injury.
A TLR4 inhibitor prevented liver damage in an ischemia / re-perfusion (I/R) injury model with additional administration of 5-FU. A TLR4 inhibitor also prevented liver damage in a bile duct ligation I/R liver injury model.
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