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Analysis of a new molecular system of branched-chain amino acids in liver damage following ischemia and re-perfusion

Research Project

Project/Area Number 25462086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

Sugawara Gen  名古屋大学, 医学部附属病院, 病院講師 (00402587)

Co-Investigator(Kenkyū-buntansha) NAGINO MASATO  名古屋大学, 医学系研究科, 教授 (20237564)
YOKOYAMA YUKIHIRO  名古屋大学, 医学部附属病院, 講師 (80378091)
KOKURYO TOSHIO  名古屋大学, 医学系研究科, 特任講師 (60378023)
ITATSU KEITA  名古屋大学, 医学系研究科, 寄附講座助教 (90534842)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肝虚血再灌流障害 / 分枝鎖アミノ酸 / 肝虚血再潅流障害
Outline of Final Research Achievements

BCAAs (branched-chain amino acids) suppress inflammatory factors, such as IL-6 (interleukin-6), TNFα (tumor necrosis factor alpha), ET1 (endothelin 1), ICAM (intercellular adhesion molecule) and VCAM (vascular cell adhesion molecule), in liver tissue of a model of ischemia / re-perfusion (I/R) injury.
A TLR4 inhibitor prevented liver damage in an ischemia / re-perfusion (I/R) injury model with additional administration of 5-FU. A TLR4 inhibitor also prevented liver damage in a bile duct ligation I/R liver injury model.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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