Development of Adipose derived meschymal stem cell therapy for liver cirrhosis
| Project/Area Number |
25462096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
Akahoshi Tomohiko 九州大学, 医学(系)研究科(研究院), 准教授 (20336019)
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| Co-Investigator(Kenkyū-buntansha) |
Hashizume Makoto 九州大学, 大学院医学研究院, 教授 (90198664)
Murata Masaharu 九州大学, 大学院医学研究院, 准教授 (30304744)
富川 盛雅 九州大学, 大学院医学研究院, 特任准教授 (60325454)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 間葉系幹細胞 / 肝硬変 / 幹細胞治療 / 門脈圧亢進症 / 脂肪由来間葉系幹細胞 / 非代償肝硬変 / 肝増殖因子 |
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| Outline of Final Research Achievements |
Background:Recent studies show that adipose tissue-derived mesenchymal stem cells(ADSC) have potential clinical applications. Here, we investigated the effect of adipose tissue-derived mesenchymal stem cells infusion on a liver fibrosis rat model and elucidated the underlying mechanism.Result:bFGF treatment markedly improved the proliferation, differentiation, and hepatocyte growth factor expression ability of ADSC. Although ADSC infusion alone slightly ameliorated liver functions and suppressed fibrosis progression, bFGF-treatment significantly enhanced the therapeutic effect in association with elevated hepatocyte growth factor expression. Co-culture with ADSC led to induction of hepatic stellate cell apoptosis and enhanced hepatocyte proliferation. Mechanism investigation revealed that co-culture with adipose tissue-derived mesenchymal stem cells activated c-jun N-terminal kinase-p53 signaling in hepatic stellate cell and promoted apoptosis.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation.2014
Author(s)
Nagao Y, Akahoshi T, Uehara H, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y
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Journal Title
Surgery Today
Volume: 44
Issue: 4
Pages: 633-639
DOI
Related Report
Peer Reviewed
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[Journal Article] Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C.2013
Author(s)
Sumida K, Shimoda S, Iwasaka S, Hisamoto S, Kawanaka H, Akahoshi T, Ikegami T, Shirabe K, Shimono N, Maehara Y, Selmi C, Gershwin ME, Akashi K.
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Journal Title
Clin Exp Immunol
Volume: 174
Issue: 1
Pages: 172-178
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients.2012
Author(s)
Kinjo N, Nagao Y, Akahoshi T, Masahiro K, Hashimoto N, Uehara H, Kawanaka H, Tomikawa M, Shirabe K, Hashizume M, Maehara Y.
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Journal Title
Hepatol Res.
Volume: in press
Issue: 9
Pages: 933-941
DOI
Related Report
Peer Reviewed
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