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Development of pancreatic cancer vaccine targeted Immune checkpoints

Research Project

Project/Area Number 25462103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKanagawa Cancer Center Research Institute (2015)
Gunma University (2013)

Principal Investigator

wada satoshi  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 研究員 (30420102)

Co-Investigator(Kenkyū-buntansha) KUBO NORIO  群馬大学, 医学部附属病院, 助教 (10464744)
SUZUKI HIDEKI  群馬大学, 医学部, 講師 (20322018)
KUWANO HIROYUKI  群馬大学, 医学(系)研究科(研究院), 教授 (90186560)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腫瘍免疫 / 免疫チェックポイント / cancer vaccine / pancreatic cancer / immune checkpoints / 膵癌
Outline of Final Research Achievements

It was evaluated in this experiment whether newly identified immune checkpoints were targets of treatment in refractory pancreatic cancer. It was analyzed the relationship between the expression and prognosis in pancreatic cancer tissue with multiple immune checkpoints. As a result, a significant difference in the relationship with the prognosis was observed in B7-H3 and B7-H4. However, a significant correlation for each expressions was not observed. This result was considered to be independent prognostic factors for each other’s. In addition, B7-H3 expression showed a reverse expression pattern in cancer cells and cancer stroma. The prognosis also became the opposite result. From the above results, it was suggested that treatment targeting novel immune checkpoints is possible alone and also in combination for refractory pancreatic cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2013

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.2016

    • Author(s)
      Tsukagoshi M, Wada S, Yokobori T, Altan B, Ishii N, Watanabe A, Kubo N, Saito F, Araki K, Suzuki H, Hosouchi Y, Kuwano H
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 2 Pages: 116-122

    • DOI

      10.1111/cas.12853

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Personalized immunotherapy in colorectal cancer.2016

    • Author(s)
      Ohtake J, Wada S, Yada E, Fujimoto Y, Uchiyama H, Yoshida S, Itoh K, Sasada T.
    • Journal Title

      Expert Rev of Prec Med and Drug Develop.

      Volume: in press Issue: 3 Pages: 267-277

    • DOI

      10.1080/23808993.2016.1174060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Xanthogranulomatous cholecystitis: Difficulty in differentiating from gallbladder cancer.2015

    • Author(s)
      Suzuki H, Wada S, Araki K, Kubo N, Watanabe A, Tsukagoshi M, Kuwano H.
    • Journal Title

      World J Gastroenterol.

      Volume: 21 Issue: 35 Pages: 10166-10173

    • DOI

      10.3748/wjg.v21.i35.10166

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Clinicopathological implications of newly defined immune checkpoints in Extra-Hepatic CholangioCarcinoma.2015

    • Author(s)
      Wada S, Tsukagoshi M, Watanabe A, Kubo N, Araki K, Suzuki H, Kuwano H.
    • Organizer
      ASCO(American Society of Clinical Oncology) 51 th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the immune suppression mechanism in extra-hepatic cholangiocarcinoma.2015

    • Author(s)
      Wada S, Tsukagoshi M, Watanabe A, Kubo N, Araki K, Suzuki H, Kuwano H.
    • Organizer
      AACR(American Association for Cancer Research) 106th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規同定されたImmune checkpoint(B7-H3, B7-H4)の膵癌組織における発現とその意義2013

    • Author(s)
      和田 聡
    • Organizer
      第113回日本外科学会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] Immune checkpointsの膵癌組織における発現とその意義2013

    • Author(s)
      和田 聡
    • Organizer
      第17回日本がん免疫学会
    • Place of Presentation
      山口県宇部市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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