| Project/Area Number |
25462104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Kohei 新潟大学, 医歯学総合病院, 助教 (70733658)
KAMEYAMA Hitoshi 新潟大学, 医歯学系, 准教授 (40626420)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 膵島移植 / 慢性膵炎 / 自家移植 / 膵臓移植 / 糖尿病 / 膵島細胞移植 / グラフト生着 |
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| Outline of Final Research Achievements |
Pancreas transplantation has already been established as an effective treatment for diabetes mellitus. However, islet transplantation is currently considered an experimental procedure because its poor results of achievement of insulin independence. Further studies is necessary to improve islet graft survival and establishment of the useful large animal model for islet transplantation is required. In current research, we successfully create a surgical diabetes model using miniature swine. We also successfully perform to establish islet autotransplantation using excised pancreas. Islets were transplanted to the liver via the portal vein. We used the techniques is applicable for clinical islet transplantation. Moreover, we showed the several important data associated with long term results after pancreas transplantation, which were created in cooperation with the high volume center in United States.
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