Pancreatectomy and islet autotransplantation for chronic pancreatitis

• Project/Area Number: 25462104
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: Kobayashi Takashi 新潟大学, 医歯学総合病院, 講師 (40464010)
• Co-Investigator(Kenkyū-buntansha): MIURA Kohei 新潟大学, 医歯学総合病院, 助教 (70733658) ; KAMEYAMA Hitoshi 新潟大学, 医歯学系, 准教授 (40626420)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 膵島移植 / 慢性膵炎 / 自家移植 / 膵臓移植 / 糖尿病 / 膵島細胞移植 / グラフト生着

Outline of Final Research Achievements

Pancreas transplantation has already been established as an effective treatment for diabetes mellitus. However, islet transplantation is currently considered an experimental procedure because its poor results of achievement of insulin independence. Further studies is necessary to improve islet graft survival and establishment of the useful large animal model for islet transplantation is required. In current research, we successfully create a surgical diabetes model using miniature swine. We also successfully perform to establish islet autotransplantation using excised pancreas. Islets were transplanted to the liver via the portal vein. We used the techniques is applicable for clinical islet transplantation. Moreover, we showed the several important data associated with long term results after pancreas transplantation, which were created in cooperation with the high volume center in United States.

Research Products

• [Presentation] Development of the autologous islet transplantation model with miniature swine (2015)
  • Author(s): Zhengkun Zhang, Kohei Miura, Takuya Ando, Kazuki Moro, Yuki Hirose, Masayuki Nagahashi, Jun Sakata, Hitoshi Kameyama, Takashi Kobayashi, Shinichi Kosugi, Toshifumi Wakai
  • Organizer: International Pancreas and Islet Transplant Association 2015
  • Place of Presentation: Melbourne
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] SUCCESSFUL ENDOSCOPIC MANAGEMENT FOR ACUTE NECROTIC PANCREATITIS AND WALLED-OFF NECROSIS AFTER AUXILIARY PARTIAL ORTHOTOPC LIVING DONOR LIVER TRANSPLANTATION: A CASE REPORT (2015)
  • Author(s): Takashi Kobayashi , Kohei Miura, Hirosuke Ishikawa, Daiki Soma, Kizuki Yuza, Yuki Hirose, Kazuyasu Takizawa, Masayuki Nagahashi, Jun Sakata, Hitoshi Kameyama, Shin-Ichi Kosugi, Toshifumi Wakai
  • Organizer: the 14th congress of asian society of transplantation
  • Place of Presentation: Singapore
  • Year and Date: 2015-08-26
  • Int'l Joint Research
• [Presentation] SUCCESSFUL RE-RESECTION FOR LOCALLY RECURRENT RETROPERITONEAL LIPOSARCOMA AT 4 YEARS AFTER EX VIVO TUMOR RESECTION AND AUTOTRANSPLANTATION OF THE LIVER: A CASE REPORT (2015)
  • Author(s): Takashi Kobayashi , Kohei Miura, Hirosuke Ishikawa, Daiki Soma, Kizuki Yuza, Yuki Hirose, Kazuyasu Takizawa, Masayuki Nagahashi, Jun Sakata, Hitoshi Kameyama, Shin-Ichi Kosugi, Toshifumi Wakai
  • Organizer: the 14th congress of asian society of transplantation
  • Place of Presentation: Singapore
  • Year and Date: 2015-08-26
  • Int'l Joint Research
• [Presentation] 6-YEAR GRAFT SURVIVAL AFTER PARTIAL PANCREAS HETEROTOPIC AUTOTRANSPLANTATION: A CASE REPORT (2015)
  • Author(s): Takashi Kobayashi , Kohei Miura, Hirosuke Ishikawa, Daiki Soma, Kizuki Yuza, Yuki Hirose, Kazuyasu Takizawa, Masayuki Nagahashi, Jun Sakata, Hitoshi Kameyama, Shin-Ichi Kosugi, Toshifumi Wakai
  • Organizer: the 14th congress of asian society of transplantation
  • Place of Presentation: Singapore
  • Year and Date: 2015-08-25
  • Int'l Joint Research
• [Presentation] 膵移植の現状と当科の経験 (2013)
  • Author(s): 小林隆
  • Organizer: 第14回新潟胆膵研究会
  • Place of Presentation: 新潟市