Strategy for treatment of advanced pancreatic cancer paying attention to chemoradiation resistant cancer stem cell

• Project/Area Number: 25462109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Mizuno Shugo 三重大学, 医学部附属病院, 講師 (70335131)
• Research Collaborator: ISAJI Shuji ; KISHIWADA Masashi ; MURATA Yasuhiro ; YAMADA Reiko ; HIBI Taemi
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 化学放射線治療 / 膵癌 / 膵癌科学放射線治療

Outline of Final Research Achievements

Our goal of this study is to establish the tailor made treatment of advanced pancreatic cancer paying attention to chemoradiation resistant cancer stem cell. We could discriminate whether the pancreatic cancer cell had chemoradiation resistance or not by using immunohistochemistry "hENT1" of sample which were obtained by EUS FNAB

Research Products

• [Journal Article] Gemcitabine-Based Chemoradiotherapy Followed by Surgery for Borderline Resectable and Locally Unresectable Pancreatic Ductal Adenocarcinoma: Significance of the CA19-9 Reduction Rate and Intratumoral Human Equilibrative Nucleoside Transporter 1 Expression. (2014)
  • Author(s): Kobayashi M, Mizuno S, Murata Y, Kishiwada M, Usui M, Sakurai H, Tabata M, Ii N, Yamakado K, Inoue H, Shiraishi T, Yamada T, Isaji S.
  • Journal Title: Pancreas Volume: 43 Issue: 3 Pages: 350-360
  • DOI: 10.1097/mpa.0000000000000059
  • Peer Reviewed
• [Presentation] Clinical significance of plasma apolipoprotein!AII isoforms as a surrogate of pancreatic exocrine in- sufficiency for patients with pancreatic adenocar- cinoma, paying attention to pancreatic morpho- logical changes including tumor after chemoradio- therapy (2016)
  • Author(s): Aoi Hayasaki, Yasuhiro Murata, Masanobu Usui, Hiroyuki Kato, Akihiro Tanemura, Naohisa Kuriyama, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Hiroyuki Sakurai, Shuji Isaji
  • Organizer: the 47th annual meeti the 47th annual meeting of the JPS and the 20th meeting of the IAPng of the JPS and the 20th meeting of the IAP
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-08-04
  • Int'l Joint Research
• [Presentation] Clinical significance of conversion surgery after gemcitabine plus S!1 based chemoradiotherapy in patients with initially locally advanced unre- sectable pancreatic adenocarcinoma:applica- tion of intratumoral expression of Tenascin C as a surrogate marker (2016)
  • Author(s): Yasuhiro Murata1, Masanobu Usui1, Aoi Hayasaki1, Yusuke Iizawa1, Hiroyuki Kato1, Akihiro Tanemura1, Naohisa Kuriyama1, Yoshinori Azumi1, Masashi Kishiwada1, Shugo Mizuno1, Hiroyuki Sakurai1, Toshimichi Yoshida2, Shuji Isaji1
  • Organizer: The Joint Conference of the 47th annual meeting of the JPS and the 20th meeting of the IAP
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-08-04
  • Int'l Joint Research
• [Presentation] 局所進行膵癌に対する化学放射線治療における腫瘍内TenascinC発現の臨床的意義の検討 (2015)
  • Author(s): 村田 泰洋、水野 修吾
  • Organizer: 日本膵臓学会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-06-19