| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Cancer stem cells (CSCs) have been studied of their self-renewal capacity and pluripotency, as well as their resistance to anti-cancer therapy and their ability to metastasize to distant organs. CSCs are difficult to study because their population is quite low in tumor specimens. To overcome this problem, we established a culture method to induce a cancer stem-like cell (CSLC)-enriched population from human cancer cell lines. Here is the problem. The surface marker of CSLC was not purely identified. CSLC is mostly recognized by combined surface markers. To develop the immunotherapy targeting CSLC, we attempted the novel detection system using RNA aptamer.
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