The development of new recognition system for cancer stem cell-like cell using RNA aptamer
| Project/Area Number |
25462113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | National Cancer Center Japan (2015)
Yamaguchi University (2013) |
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Principal Investigator |
YOSHIMURA KIYOSHI 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (30346564)
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| Co-Investigator(Kenkyū-buntansha) |
KUREAMASU ATSUO 山口大学, 医学(系)研究科(研究院), 准教授 (90302091)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌幹細胞 / 膵癌幹細胞 / 免疫療法 / ＲＮＡアプタマー / 膵癌 / RNAアプタマー / アプタマー / がん免疫療法 |
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| Outline of Final Research Achievements |
Cancer stem cells (CSCs) have been studied of their self-renewal capacity and pluripotency, as well as their resistance to anti-cancer therapy and their ability to metastasize to distant organs. CSCs are difficult to study because their population is quite low in tumor specimens. To overcome this problem, we established a culture method to induce a cancer stem-like cell (CSLC)-enriched population from human cancer cell lines. Here is the problem. The surface marker of CSLC was not purely identified. CSLC is mostly recognized by combined surface markers. To develop the immunotherapy targeting CSLC, we attempted the novel detection system using RNA aptamer.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice.2015
Author(s)
51.Ishiguro S, Yoshimura K, Tsunedomi R, Oka M, Takao S, Inui M, Kawabata A, Wall T, Magafa V, Cordopatis P, Tzakos AG, Tamura M.
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Journal Title
Cancer Biol Ther.
Volume: 16
Pages: 307-316
Related Report
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[Journal Article] Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial.2015
Author(s)
52.Maeda Y, Yoshimura K, Matsui H, Shindo Y, Tamesa T, Tokumitsu Y, Hashimoto N, Tokuhisa Y, Sakamoto K, Sakai K, Suehiro Y, Hinoda Y, Tamada K, Yoshino S, Hazama S, Oka M.
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Journal Title
Cancer Immunol Immunother.
Volume: 64
Pages: 1047-1056
Related Report
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