The basic research for establishment of a new strategy for IBMIR control in islet transplantation by ADSC

• Project/Area Number: 25462114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: IKEMOTO Tetsuya 徳島大学, 大学院医歯薬学研究部, 助教 (20398019)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Mitsuo 徳島大学, 大学院医歯薬学研究部, 教授 (10216070) ; IMURA Satoru 徳島大学, 病院, 特任教授 (90380021) ; MORINE Yuji 徳島大学, 大学院医歯薬学研究部, 講師 (60398021) ; SAITO Yu 徳島大学, 大学院医歯薬学研究部, 助教 (50548675) ; YAMADA Shinichiro 徳島大学, 病院, 特任助教 (30579884) ; IWAHASHI Shuichi 徳島大学, 大学院医歯薬学研究部, 特任助教 (30531751) ; UTSUNOMIYA Toru 徳島大学, 大学院医歯薬学研究部, 准教授 (30304801) ; KANAMOTO Mami 徳島大学, 大学院医歯薬学研究部, 助教 (10448326) ; ARAKAWA Yusuke 徳島大学, 大学院医歯薬学研究部, 助教 (00448325)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: IBMIR / ADSC / trophic effect / blood coagulation system / 膵島移植 / 移植免疫

Outline of Final Research Achievements

This project revealed that ADSC had the trophic effect for injured islet though VEGF signaling. As in vivo study, ADSC were trapped in reticuloendothelial system, not in injured pancreas when they were administered intravenously. Mouse coagulation system analysis and porcine islet-whole blood co-culture system revealed that the effects on these systems by ADSC were very small and required large amount of ADSC even though these effects were ADSC dose-dependent manner.

Research Products

• [Journal Article] Clinical Role of Notch Signaling Pathway in Intraductal Papillary Mucinous Neoplasm of the Pancreas. (2015)
  • Author(s): Ikemoto T,Sugimoto K,Shimada M,Utsunomiya T,Morine Y, Imura S, Arakawa Y, Kanamoto M, Iwahashi SI, Saito Y, Yamada S
  • Journal Title: J Gastroenterol Hepatol. Volume: 30 Issue: 1 Pages: 217-222
  • DOI: 10.1111/jgh.12660
  • Peer Reviewed
• [Presentation] 脂肪由来幹細胞による膵島細胞移植成績向上に関する新たな治療戦略 (2016)
  • Author(s): 池本 哲也
  • Organizer: 第43回日本膵・膵島移植研究会
  • Place of Presentation: ホテルグランヴィア広島（広島県広島市）
  • Year and Date: 2016-03-04
• [Presentation] 脂肪由来幹細胞が拓く膵島細胞移植成績向上に関する展望と課題 (2015)
  • Author(s): 池本哲也.島田光生,居村暁,森根裕二,齋藤裕,山田眞一郎,寺奥大貴,吉川雅登
  • Organizer: 第51回日本移植学会総会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-10-03
• [Presentation] Xenotransplant Immune response is reduced by Japanese kampo medicine TJ-114 through Foxp3+regulatory T cells (2015)
  • Author(s): Masato Yoshikawa, Mitsuo Shimada, Tetsuya Ikemoto.
  • Organizer: European Society for Organ Transplantation 2015
  • Place of Presentation: Square-Brussels Meeting Centre(Brussels,Belgium)
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] Japanese Herbal Medicine TJ-114 prevents autoimmune diabetes onsets in NOD mice through CD4+CD49b+regulatory T cells (2015)
  • Author(s): Tetsuya Ikemoto, Mitsuo Shimada.
  • Organizer: European Society for Organ Transplantation
  • Place of Presentation: Square-Brussels Meeting Centre(Brussels,Belgium)
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] 脂肪由来幹細胞を用いた肝胆膵領域の再生医療に関するimpactと課題 (2013)
  • Author(s): 池本哲也 島田光生, 宇都宮徹, 居村暁, 森根裕二, 森大樹, 荒川悠佑, 金本真美, 齋藤裕, 山田眞一郎, 淺野間理仁, 三宅秀則
  • Organizer: 第113回日本外科学会総会
  • Place of Presentation: 福岡国際会議場(福岡県)