| Project/Area Number |
25462115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
Okano Keiichi 香川大学, 医学部附属病院, 准教授 (20314916)
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| Co-Investigator(Kenkyū-buntansha) |
YACHIDA Shinichi 独立行政法人国立がん研究センター, 研究所, ユニット長 (20359920)
SUZUKI Yasuyuki 香川大学, 医学部, 教授 (40304092)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵神経内分泌腫瘍 / TSC2 / P53 / DAXX / ATRX / MEN1 / PTEN / PNET |
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| Outline of Final Research Achievements |
The number of patients with pancreatic neuroendocrine tumor (PNETs) has been increased. The genetic and clinicopathologic features are still unclear. In this study, we analyzed the genetic changes and clinicopathological features of PNETs. The specimens from 88 patients with PNETs (multicenter study) were classified according to the 2010WHO classification. Five major genes of PNETs (DAXX, ATRX, MEN1, TSC2, PTEN) were examined. The immunohistochemical staining results revealed that significant association of ATRX and liver metastasis, TSC2 (Tuberin) and post-operative recurrence. The p53 abnormality showed significant correlation with PNETs Grade classification (G1/2).
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