| Project/Area Number |
25462122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今村 将史 札幌医科大学, 医学部, 講師 (00404608)
伊東 竜哉 札幌医科大学, 医学部, 助教 (10516636)
秋月 恵美 札幌医科大学, 医学部, 研究員 (20404626)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 膵頭十二指腸切除 / 胃排泄遅延 / Delayed gastric emptying / DGE / 食事摂取量 / 膵臓外科学 / 消化器外科学 / 膵頭十二指腸切除切除 / 六君子湯 |
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| Outline of Final Research Achievements |
Randomized control trial was conducted to evaluate the clinical efficacy of Rikkunnsito(TJ-43) on reducing delayed gastric emptying(DGE) after pancreaticoduodenectomy. A total of 58 patients who scheduled for surgeries were enrolled to this study and randomized to either 26 patients for observation group or 27 patients for interventional group with administration of TJ-43 postoperatively, excluding 5 patients with drop out due to intraoperative finding not permitting the completion of surgeries. DGE developed in 4 patients of observational group(15.4%) and in 5 patients of TJ-43 group(18.5%). There was no significant difference between two groups(p=0.5437, chi-square test).
Rikkunnsito profilaxis for the prevention of DGE after pancreaticoduodenectomy was not proved to be efficient though this randomized control trial(UMIN000012052).
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