| Project/Area Number |
25462129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
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Principal Investigator |
TANEMURA Masahiro 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 (30379250)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Eiji 大阪大学, 医学系研究科, 教授 (20322183)
EGUCHI Hidetoshi 大阪大学, 医学系研究科, 准教授 (90542118)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵癌 / 循環癌細胞 / 癌幹細胞 / 糖鎖 / 創薬 / テロメスキャン / 循環器細胞 |
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| Outline of Final Research Achievements |
The detection of increase in the number of circulating tumor cells (CTCs) during a patient’s clinical course may be a harbinger of forthcoming overt metastasis. To detect live CTCs (l-CTCs) in blood samples of patients (pts), we employed a genetically modified telomerase-specific replication-selective adenovirous, expressing GFP (TelomeScanF35). We assessed the l-CTCs burden in pts treated with NACRT. 15 pts aged 44-78 years (4 males, 11 females) were enrolled. 5 of 15 enrolled pts had l-CTCs detected before NACRT. An increase in CTCs was seen in 4 of 5 pts after NACRT, but no detectable l-CTCs were observed in only 1 pt after NACRT. These 4 CTC-positive pts continuously had CTCs detected after surgery. 2 of 4 CTC-positive pts early developed liver metastasis and died, despite R0 resection. We may consider surgery first for the CTC-positive pts before NACRT. The capture of l-CTCs may be useful biomarker for prognosis assessment or stratification.
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