Establishment of atrial fibrillation surgery indicated by frequency analysis of fibrillation waves using holter ECG.

• Project/Area Number: 25462133
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: University of Toyama
• Principal Investigator: Fukahara Kazuaki 富山大学, 大学院医学薬学研究部(医学), 准教授 (40343181)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Naoki 富山大学, 大学院医学薬学研究部(医学), 教授 (20401804) ; NAGURA Saori 富山大学, 附属病院, 助教 (90401843)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 心臓大血管外科学 / 心房細動 / 周波数解析 / ホルター心電図 / 手術

Outline of Final Research Achievements

To investigate the mechanisms of chronic atrial fibrillation (AF) and reduce ablation lines for the surgical treatment of AF, we performed the frequency analysis of fibrillation waves using holter electrograms. Electrical potentials of fibrillation waves in the body surface were directly collected with 24 hours and high-sensitivity holter electrograms. Atrial electrograms filtered between 0.5 Hz and 60 Hz were recorded for 20 seconds and four-second segments of each electrograms were subjected to fast Fourier transform analysis to calculate the fibrillation cycle length (FCL).
From the data of the FCL, we decided the ablation lines at AF surgery. However it was difficult to identify the targets and substrates of the AF. Accordingly we tried to investigate the method to detect accurate fibrillation waves and found three dimensional (3D) mapping systems could be used to detect frequency analysis of fibrillation waves. This method may be helpful for the surgical treatment of AF.

Research Products

• [Presentation] Complex fractionated atrial electrograms (CFAE) mappingを指標とした心房細動手術 (2016)
  • Author(s): 深原 一晃、名倉 里織、酒井 麻里、芳村 直樹
  • Organizer: 第46回 日本心臓血管外科学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2016-02-15
• [Presentation] Frequency Analysis of Fibrillation Waves for the Surgical Treatment of Atrial Fibrillation. (2015)
  • Author(s): Kazuaki Fukahara, Saori Nagura, Toshio Doi, Naoki Yoshimura.
  • Organizer: ISMICS Annual Scientific Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2015-06-03
  • Int'l Joint Research