Regulation of pathologic cardiac remodeling targeting a hypoxia response system using a sonoporation.

• Project/Area Number: 25462134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Gifu University
• Principal Investigator: MATSUNO Yukihiro 岐阜大学, 大学院医学系研究科, 非常勤講師 (10542409)
• Co-Investigator(Kenkyū-buntansha): TAKEMURA Hirofumi 金沢大学, 医学系, 教授 (20242521) ; SHIMABUKURO Katsuya 岐阜大学, 医学部附属病院, 講師 (20362163)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 心筋疾患外科学 / 遺伝子治療 / 心筋リモデリング / 低酸素応答 / 超音波

Outline of Final Research Achievements

In this study, we aimed that regulation of pathologic cardiac remodeling targeting a hypoxia response system using a sonoporation.
We performed GFP gene delivery in vitro, and confirmed the gene expression in vivo.