• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of selective cerebral perfusion to prevent brain injury in children with congenital cardiac diseases and its application for adult patients

Research Project

Project/Area Number 25462139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionNagoya City University

Principal Investigator

MISHIMA Akira  名古屋市立大学, 大学院医学研究科, 教授 (00254277)

Co-Investigator(Kenkyū-buntansha) 浅野 実樹  常葉大学, 健康プロデュース学部, 教授 (20275134)
鵜飼 知彦  名古屋市立大学, 大学院医学研究科, 講師 (40347399)
野村 則和  名古屋市立大学, 大学院医学研究科, 講師 (80363935)
Research Collaborator ISHIDA Akimasa  名古屋市立大学, 大学院医学研究科, 助教 (20632607)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords選択的脳灌流 / 脳虚血モデル / 肺高血圧 / 低酸素血症 / 若齢ラット / 幼若ラット
Outline of Final Research Achievements

In cardiac surgery of children with anomaly of the aortic arch, brain blood is supplied by a particular method, called selective cerebral perfusion under using cardiopulmonary bypass. We devised a simple selective cerebral perfusion model on rats. To develop an adequate procedure for children with cyanosis, we conducted experiment on selective cerebral perfusion in juvenile rats bred under hypoxic environment. Neural damage of brain was investigated with a special microscopic examination that detected early neural injury. Brain damage caused by the selective cerebral perfusion was more serious in juvenile rats bred under hypoxic environment than in normal rats. So, we should be careful about the selective cerebral perfusion of children with cyanosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2017

All Presentation (3 results)

  • [Presentation] 若齢肺高血圧ラットでは選択的脳還流による虚血脳障害が高率に発生する2017

    • Author(s)
      三島 晃、松前秀和、野村則和、石田章真
    • Organizer
      第53回日本小児循環器学会総会・学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 椎骨動脈切断モデルを用いた選択的脳灌流による早期脳障害の病理学的検討2017

    • Author(s)
      三島 晃、松前秀和、野村則和、石田章真
    • Organizer
      第117回日本外科学会定期学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2017-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 選択的脳灌流による若齢ラットの早期脳障害の解析2017

    • Author(s)
      三島 晃、松前秀和、野村則和、石田章真
    • Organizer
      第47回日本心臓血管外科学会学術総会
    • Place of Presentation
      グランド日航東京台場(東京都・港区)
    • Year and Date
      2017-02-27
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi