Thin expanded polytetrafluoroethylene pulmonary valve and polytetrafluoroethylene conduit with bulging sinus

• Project/Area Number: 25462140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Yamagishi Masaaki 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40182422)
• Co-Investigator(Kenkyū-buntansha): Maeda Yoshinobu 京都府立医科大学, 大学院医学研究科, 助教 (20438203) ; Miyazaki Takako 京都府立医科大学, 大学院医学研究科, 助教 (90405291)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺動脈弁 / 右室流出路形成 / ePTFE / 人工血管 / ポリテトラフルオロエチレン

Outline of Final Research Achievements

We performed clinical use of newly developed tricuspid fan-shaped pulmonary valve using the ultra-thin ePTFE membrane and ePTEF conduit with bulging sinus for right ventricular outflow reconstruction. The diameter of the conduit was 16.4±4.0mm. The pressure gradient was 13.2±8.6mmHg in the large-diameter group (more than 18mm) and 16.3±10.4mmHg in the small diameter group (16mm or less). It was suggested that the ultra-thin ePTFE membrane valve effective technology for preventing stenosis. Pulmonary regurgitation significantly increased in a large-diameter (22, 24mm) conduit.

Research Products

• [Journal Article] Current status of right ventricular outflow tract reconstruction: complete translation of a review article originally published in Kyobu Geka 2014;67:65-77. (2015)
  • Author(s): Yamamoto Y
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 63 Issue: 3 Pages: 131-141
  • DOI: 10.1007/s11748-014-0500-0
  • Peer Reviewed / Open Access
• [Journal Article] 右室流出路再建術 (2014)
  • Author(s): 山本裕介、山岸正明
  • Journal Title: 胸部外科 Volume: 67 Pages: 65-77
  • NAID: 40019921190
• [Journal Article] 胸部外科領域における再手術－最近の動向. 再右室流出路再建術 (2013)
  • Author(s): 宮崎隆子、山岸正明
  • Journal Title: 胸部外科 Volume: 66 Pages: 607-673
• [Presentation] 先天性心疾患に対する右室流出路再建術 ～ Fan-shaped ePTFE valve・bulging sinus ePTFE patch/conduitの開発と臨床応用 ～ (2015)
  • Author(s): 山岸正明
  • Organizer: 第22回 東海胸部人工臓器カンファレンス
  • Place of Presentation: 名古屋
  • Year and Date: 2015-09-26
  • Invited
• [Presentation] 純型肺動脈閉鎖症に対する外科的治療戦略 (2015)
  • Author(s): 宮崎隆子
  • Organizer: 第51回日本小児循環器学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-16
• [Presentation] fan-shaped ePTFE valved conduit with bulging sinus のさらなる進化を目指して. ―新型導管の有効性に関する検討― (2015)
  • Author(s): 山本裕介
  • Organizer: 第51回日本小児循環器学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-16
• [Presentation] Fan-shaped ePTFE valve付 bulging sinus ePTFE conduit/patchを用い右室流出路再建術 -多施設共同研究- (2015)
  • Author(s): 山岸正明
  • Organizer: 第58回関西胸部外科学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2015-06-12
  • Invited
• [Presentation] 先天性心疾患再手術回避のための手術術式の工夫 (2015)
  • Author(s): 山岸正明
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-16
  • Invited
• [Presentation] Fan-shaped ePTFE valveとbulging sinus ePTFE conduit/patchを用いた右室流出路再建術の遠隔成績 －本邦63施設共同研究－ (2015)
  • Author(s): 宮崎隆子、山岸正明、前田吉宣
  • Organizer: 第50回日本小児循環器学会
  • Place of Presentation: 岡山
• [Presentation] Current Strategy for Right Ventricular Outflow Reconstruction (2014)
  • Author(s): 山岸正明、宮崎隆子、前田吉宣
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Expanded Polytetrafluoroethylene Valved Conduits and Patched with Bulging Sinus and Fanshaped Valves in Right Ventricular Outflow Tract Reconstruction (2013)
  • Author(s): 宮崎隆子、山岸正明
  • Organizer: The 21th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Fan-shaped ePTFE valveとbulging sinus ePTFE conduit/patchによる右室流出路再建術 (2013)
  • Author(s): 山岸正明、宮崎隆子、前田吉宣
  • Organizer: 日本医工学治療学会第29回学術大会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 心室中隔欠損兼肺動脈閉鎖の治療戦略 (2013)
  • Author(s): 宮崎隆子、山岸正明、前田吉宣
  • Organizer: 第49回日本小児循環器学会総会・学術集会
  • Place of Presentation: 東京
• [Remarks] Bulging sinus及びePTFE弁付パッチ（または導管）による右室流出路再建術
  • URL: http://www.cvs-kpum.com/pe_cardiova/measure.html