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Surgical Strategy for Aortic Arch Reconstruction after Norwood Procedure based on a Virtual Operation with Numerical Flow Analysis

Research Project

Project/Area Number 25462145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionWakayama Medical University (2015)
Kitasato University (2013)

Principal Investigator

Oka Norihiko  和歌山県立医科大学, 医学部, 講師 (20328420)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血流解析 / 先天性心疾患 / 数値流体シミュレーション / 画像診断 / 血流可視化 / 心機能 / エネルギー損失 / 先天性大動脈疾患
Outline of Final Research Achievements

In the first year, using vector flow mapping (VFM) based on echocardiography, the flow in a reconstructed aortic arch after Norwood operation was analyzed as a pilot data. We validated that the result of VFM analysis was compatible with that of computational fluid dynamics (CFD). In the second year, we validated the reliability of VFM analysis by comparing the date with 4DMRI analysis. Further data accumulation was achieved and reached up to 24 cases in this year. By analyzing the data, we found that the reconstructed aortic arch with more than 70 Pascal of shear stress would affect patients’ cardiac function and requires reoperation. In the third year, we confirmed that the reoperation for the aortic arch with more than 70 of shear stress Pascal certainly reduces energy loss that may improve the patients’ cardiac function in a long term.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (5 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Norwood Procedure Performed on a Patient With Trisomy 132016

    • Author(s)
      Norihiko Oka; Takamichi Inoue; Miyuki Shibata; Takeshi Yoshii; Yuki Nakamura; Haruna Araki; Yoshikiyo Matsunaga; Tomoki Tamura; Keiichi Itatani; Tetsuya Horai; Tadashi Kitamura; Shinzo Torii; Kagami Miyaji
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 1 Pages: 121-122

    • DOI

      10.1536/ihj.15-186

    • NAID

      130005120999

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of the entry site on late outcome in acute Stanford type B aortic dissection†.2015

    • Author(s)
      Kitamura T, Torii S, Oka N, Horai T, Itatani K, Yoshii T, Nakamura Y, Shibata M, Tamura T, Araki H, Matsunaga Y, Sato H, Miyaji K
    • Journal Title

      European Journal of Cardiothoracic Surgery

      Volume: 48 Issue: 5 Pages: 655-661

    • DOI

      10.1093/ejcts/ezu531

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical utility of the plasma brain natriuretic peptide level in monitoring tetralogy of fallot patients over the long term after initial intracardiac repair: considerations for pulmonary valve replacement.2015

    • Author(s)
      Kitagawa A, Oka N, Kimura S, Ando H, Honda T, Takanashi M, Mineo E, Miyaji K, Ishii M
    • Journal Title

      Pediatric Cardiology

      Volume: 36 Issue: 4 Pages: 752-758

    • DOI

      10.1007/s00246-014-1075-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seventeen-month-long paracorporeal biventricular mechanical support as a bridge to transplantation for severe dilated cardiomyopathy2015

    • Author(s)
      Kitamura T, Torii S, Oka N, Horai T, Itatani K, Yoshii T, Nakamura Y, Shibata M, Tamura T, Araki H, Matsunaga Y, Miyaji K.
    • Journal Title

      J Artif Organs

      Volume: 18 Issue: 1 Pages: 92-94

    • DOI

      10.1007/s10047-014-0797-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血流可視化技術が切り開く循環器画像診断の新たな領域:心臓超音波VFM (Vector Flow Mapping)の現状と展望2014

    • Author(s)
      板谷慶一 宮崎翔平 小山紗千 中島光貴 宝来哲也 岡徳彦 北村律 本田崇 鍋田健 佐藤孝典 石井正浩 阿古潤也 宮地鑑
    • Journal Title

      Medix

      Volume: 60 Pages: 17-21

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraventricular flow velocity visualization based on the continuity equation and measurements of vorticity and wall shear stress.2013

    • Author(s)
      ItataniK, Okada T, Uejima T, Tanaka T, Ono M, Miyaji K, Takenaka K
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 52 Issue: 7S Pages: 07HF16-07HF16

    • DOI

      10.7567/jjap.52.07hf16

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neutrophil Elastase Inhibitor Sivelestat Attenuates Perioperative Inflammatory Response in Pediatric Heart Surgery With Cardiopulmonary Bypass2013

    • Author(s)
      Inoue N, Oka N, Kitamura T, Shibata K, Itatani K, Tomoyasu T, Miyaji K.
    • Journal Title

      International Heart Journal

      Volume: 54 Issue: 3 Pages: 149-153

    • DOI

      10.1536/ihj.54.149

    • NAID

      130003364460

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of the Neutrophil Elastase Inhibitor Sivelestat on Perioperative Inflammatory Response After Pediatric Heart Surgery with Cardiopulmonary Bypass: A Prospective Randomized Study. Artif Organs.2013

    • Author(s)
      Kohira S, Oka N, Inoue N, Itatani K, Hanayama N, Kitamura T, Fujii M, Takeda A, Oshima H, Tojo K, Yoshitake S, Miyaji K.
    • Journal Title

      Artificial Organs

      Volume: 37 Pages: 1027-33

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Surgical Strategy for Aortic Arch Reconstruction after Norwood Procedure based on a Virtual Operation with Numerical Flow Analysis2016

    • Author(s)
      Miyazaki S, Itatani K, Oka N, Goto S, Nakamura M, Kitamura T, Horai T, Nakamura Y, Miyaji K
    • Organizer
      96th Annual Meeting of American Association for Thoracic Surgery
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2016-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mechanisms of the single ventricular physiology.

    • Author(s)
      Itatani K, Miyaji K, Miyazaki S, Honda T, Oka N, Kitamura T, Torii S, Ishii M, Umezu M
    • Organizer
      IEEE EMBC 2013
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] New perspective: when the blood flow becomes bright Intraventricular Flow Patterns: From Normality to Pathology

    • Author(s)
      Itatani K, Oka N, Honda T, Miyazaki S, Kitamura T, Miyaji K
    • Organizer
      Euro Echo Imaging 2013
    • Place of Presentation
      イスタンブール
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 段階的フォンタン手術の術式決定に際し血流解析が有用であったDORV、TGA、Hypoplastic aortic arch、Large VSDの一例

    • Author(s)
      荒記春奈 岡徳彦 波里陽介 板谷慶一 中島光貴 宝来哲也 北村律 鳥井晋三 宮地鑑
    • Organizer
      第164回 日本胸部外科学会関東甲信越地方会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 単心室症におけるFontan 手術後の血行動態予測を目的とした数値流体解析のための境界条件の検討 On the Boundary Conditions of the Computational Fluid Dynamics Models for the Evaluation of Hemodynamics after the Fontan Procedure in Single Ventricular Physiology

    • Author(s)
      後藤真治 中村匡徳 板谷慶一 平原裕行 宮崎翔平 岡徳彦 本田崇 北村律 宝来哲也 石井正浩 宮地鑑
    • Organizer
      日本機械学会 関東支部 関東学生会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Book] Advances in Hemodynamics Research2015

    • Author(s)
      Shohei Miyazaki, Keiichi Itatani, Sachi Koyama, Kouki Nakashima, Tetsuya Horai, Norihiko Oka, Tadashi Kitamura and Kagami Miyaji
    • Total Pages
      302
    • Publisher
      Nova Science Publishers
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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