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Role of neural crest cells in bicuspic aortic valve

Research Project

Project/Area Number 25462147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionYamazaki Gakuen University (2015)
Tokyo Women's Medical University (2013)

Principal Investigator

Miyagawa-Tomita Sachiko  ヤマザキ学園大学, 公私立大学の部局等, 教授 (40231451)

Research Collaborator NAGAO Hiroaki  東京女子医科大学, 医学部, 技師
MAEDA Kazuhiro  東京女子医科大学, 医学部, 大学院生
SEYA Daiki  東京大学, 大学院医学研究科, 大学院生
MARUYAMA Kazuaki  東京大学, 大学院医学研究科, 大学院生
KURIHARA Hiroki  東京大学, 大学院医学研究科, 教授
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords大動脈弁 / 二弁性大動脈弁 / 神経堤細胞 / 1細胞解析 / 二尖弁 / 1細胞解析 / Semapholin3E / 先天性心疾患
Outline of Final Research Achievements

The aortic valve which consists of three valve leaflets prevents regurgitant blood flow at the outflow tract of the left ventricle. Bicuspid aortic valve is the most common congenital heart defect, occurring in 0.5% to 2% of the general population, with a higher prevalence in men. Mature aortic valves are stratified into extracellular matrix layers rich in elastin (ventricularis), proteoglycan (spongiosa) and collagen (fibrosa). Formation of the aortic valve is involved in endocardial cells, second heart field derived cells, and neural crest derived cells. In our research, postotic and preotic neural crest cells were shown distinctive patterns in the aortic valve leaflets. And we confirmed that neural crest cells were involved in the development of the ascending aorta.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (21 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.2015

    • Author(s)
      Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Neme N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6853-6853

    • DOI

      10.1038/ncomms7853

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.2015

    • Author(s)
      Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H
    • Journal Title

      Developmental Biology

      Volume: 15 Issue: 2 Pages: 162-174

    • DOI

      10.1016/j.ydbio.2015.04.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.2015

    • Author(s)
      Moriya M, Inoue S, Miyagawa-Tomita S, Nakashima Y, Oba D, Niihori T, Hashi M, Ohnishi H, Kure S, Matsubara Y, Aoki Y.
    • Journal Title

      Hum Mol Genet.

      Volume: 24 Issue: 25 Pages: 7349-7360

    • DOI

      10.1093/hmg/ddv435

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postotic and preotic neural crest cells differently contribute to thyroid development.2015

    • Author(s)
      Kazuhiro Maeda, Rieko Asai, Kazuaki Maruyama, Yukiko Kurihara, Toshio Nakanishi, Hiroki Kurihara, Sachiko Miyagawa-Tomita.
    • Journal Title

      Dev Biol

      Volume: 409 Issue: 1 Pages: 72-83

    • DOI

      10.1016/j.ydbio.2015.10.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hesr2 knockout mice develop aortic valve disease with advancing age2013

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, Nakashima Y, Kume T, Yoshizumi M, Nakanishi T, Saga Y.
    • Journal Title

      Arterioscler Thromb Vascular Biology

      Volume: 33 Issue: 3 Pages: 84-92

    • DOI

      10.1161/atvbaha.112.300573

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.2013

    • Author(s)
      Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T
    • Journal Title

      Mech Dev.

      Volume: 130 Issue: 11-12 Pages: 519-31

    • DOI

      10.1016/j.mod.2013.07.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Semaphorin 3E-PlexD1 signaling regulate the proper coronary artery development.2016

    • Author(s)
      Kazuaki Maruyama, Sachiko Miyagawa-Tomit , Yuichiro Arima, Daiki Seya, Kazuaki Naemura, Akiyoshi Uemura, Yutaka Yoshida, Mann Fanny, Yukiko Kurihara, Hiroki Kurihara
    • Organizer
      Weinstein Cardiovascular Development and Regeneration Conference2016
    • Place of Presentation
      Darham, USA
    • Year and Date
      2016-05-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.2016

    • Author(s)
      Shin-ichi Inoue, Mitsuji Moriya, Sachiko Miyagawa-Tomita, Yasumi Nakashima, Daiju Oba, Tetsuya Niihori, Misato Hashi, Hiroshi Ohnishi, Shigeo Kure, Yoichi Matsubara and Yoko Aoki
    • Organizer
      The 13th International Congress of Human Genetics
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2016-04-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic research in a mouse model of cardio-facio-cutaneous syndrome.2016

    • Author(s)
      Daiju Oba, Shin-ichi Inoue, Mitsuji Moriya, Yusuke Watanabe, Tetsuya Niihori, Sachiko Miyagawa-Tomita, Shigeo Kure, Toshihiko Ogura, Yoichi Matsubara, Yoko Aoki
    • Organizer
      The 13th International Congress of Human Genetics
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2016-04-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心流出路に遊走する神経堤細胞の系譜とレチノイン酸の作用の検討2015

    • Author(s)
      瀬谷大貴、宮川-富田幸子、有馬勇一郎、淺井理恵子、丸山和晃、内島泰信、栗原由紀子、栗原裕基.
    • Organizer
      第14回日本心臓血管発生研究会
    • Place of Presentation
      ホテル華の湯(福島県郡山市)
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1は冠動脈形成に重要な役割を果たす.2015

    • Author(s)
      丸山和晃、宮川-富田幸子、有馬勇一郎、瀬谷大貴、苗村和明、上村明嘉、吉田豊、Mann Fanny、栗原由紀子、栗原裕基
    • Organizer
      第14回日本心臓血管発生研究会
    • Place of Presentation
      ホテル華の湯(福島県郡山市)
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1は冠動脈形成に重要な役割を果たす2015

    • Author(s)
      丸山和晃、宮川-富田幸子、有馬勇一郎、瀬谷大貴、苗村和明、上村明嘉、吉田豊、Mann Fanny、栗原由紀子、栗原裕基.
    • Organizer
      第23回日本血管生物医学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] がん原遺伝子BRAFの機能獲得性変異は先天性異常を引き起こす2015

    • Author(s)
      井上晋一1, 守谷充司1,2, 宮川-富田幸子3, 中嶌八隅4, 大場大樹1, 新堀哲也1, 橋美里5, 大西浩史5, 呉繁夫2, 松原洋一1,6, 青木洋子1
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1シグナルが冠血管形成には重要である.2015

    • Author(s)
      丸山和晃、宮川-富田幸子、栗原裕基
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin 3E-Plexin D1 signaling is important for coronary artery formation.2015

    • Author(s)
      Maruyama K, Miyagawa-Tomita S, Kurihara H.
    • Organizer
      Weinstein Cardiovascular Development Conference 2015
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-04-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Endothelin receptor type A expressing cell population in the inflow tractcontributes to chamber formation and cardiac conduction system development2013

    • Author(s)
      Rieko Asai, Yuichiro Arima, Daiki Seya, Ki-Sung Kim, Yumiko Kawamura,Yukiko Kurihara, Sachiko Miyagawa-Tomita, Hiroki Kurihara
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Tucson, AZ, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] The preotic neural crest directly contributes to the coronary arteries2013

    • Author(s)
      Sachiko Miyagawa-Tomita, Yuichiro Arima, Kazuhiro Maeda, Rieko Asai, Ki-Sung Kim, Daiki Seya, Maryline Minoux, Filippo M. Rijli, Koichi Nishiyama, Yasunobu, Uchijima, Toshio Nakanishi1, Hisao Ogawa, Yukiko Kurihara and Hiroki Kurihara
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Tucson, AZ, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] The role of thyroid hormone in developing heart2013

    • Author(s)
      Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Toshio Nakanishi
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      島根
    • Related Report
      2013 Research-status Report
  • [Presentation] Endothelin receptor type A expressing cell population in the inflow tract contributes to chamber formation and conduction system development2013

    • Author(s)
      Asai R, Arima Y, Seya D, Kim KS, Kawamura Y, Kurihara Y, Miyagawa-Tomita S, Kurihara H
    • Organizer
      The 7th Takao International symposium on Etiology and Morphogenesis of Congenital Heart Disease
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] he role of thyroid hormone in developing heart2013

    • Author(s)
      Maeda K, Miyagawa-Tomita S, Nakanishi T
    • Organizer
      The 7th Takao International symposium on Etiology and Morphogenesis of Congenital Heart Disease
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] The preotic neural crest; a novel origin of coronary artery smooth muscle2013

    • Author(s)
      Kurihara H, Arima Y, Maeda K, Asai R, Kurihara Y, Miyagawa-Tomita S
    • Organizer
      The 7th Takao International symposium on Etiology and Morphogenesis of Congenital Heart Disease
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] The “cardiac neural crest” concept revisited2013

    • Author(s)
      Miyagawa-Tomita S, Maeda K, Arima Y, Asai R, Kurihara Y, Kurihara H, Nakanishi T
    • Organizer
      The 7th Takao International Symposium on etiology and morphogenesis of congenital heart disease
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] 鼓膜の発生とエンドセリン―Dlx5/6経路:ほ乳類とハ虫類の比較発生学2013

    • Author(s)
      北沢太郎、久米秀明、宮川-富田幸子、栗原裕基
    • Organizer
      第36回日本分子発生生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] The “cardiac neural crest” concept revisited2013

    • Author(s)
      宮川-富田幸子、前田和宏、有馬勇一郎、淺井理恵子、中西敏雄、栗原由紀子、栗原裕基
    • Organizer
      第36回日本分子発生生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 心室発生の分子生物学的メカニズム

    • Author(s)
      富田幸子
    • Organizer
      東京女子医科大学心研小児科夏季セミナー
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The preotic neural crest directly contributes to the coronary arteries

    • Author(s)
      Miyagawa-Tomita S, Arima Y, Maeda K, Asai R, Kim KS, Seya D, Minoux M, Rijli FM, Nishiyama K, Uchijima Y, Nakanishi T, Ogawa H, Kurihara Y, Kurihara H
    • Organizer
      東京女子医科大学学内研究交流セミナー
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺および心臓血管系の形態形成における関係

    • Author(s)
      前田和宏、宮川‐富田幸子、中西敏雄
    • Organizer
      東京女子医科大学学内研究交流セミナー
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] Etiology and morphogenesis of congenital heart disease2016

    • Author(s)
      Sachiko Miyagawa-Tomita, Arima, Hiroki Kurihara
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Etiology and morphogenesis of congenital heart disease2016

    • Author(s)
      Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Toshio Nakanishi.
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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