Surgical modification of interatrial conduction pathway in the treatment of atrial fibrillation

• Project/Area Number: 25462150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Nippon Medical School
• Principal Investigator: Sakamoto Shunichiro 日本医科大学, 医学部, 講師 (50398872)
• Co-Investigator(Kenkyū-buntansha): HIROMOTO ATSUSHI 日本医科大学, 医学部, 助教 (80465327) ; 渡邉 嘉之 日本医科大学, 医学部, 助教 (80445791)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 心房細動 / 心房間伝導路 / 外科手術

Outline of Final Research Achievements

Interatrial conduction was not influenced by the shortened effective refractory period in the atrium with acetylcholine infusion. The bachmann’s bundle was the primary interatrial conduction pathway which was determined by the stimulated site and direction of atrial activation. The radiofrequency ablation on bachmann’s bundle delayed the epicardial interatrial conduction. However, the total atrial activation time in both both was maintained by interatrial septal conduction. The bachmann’s bundle ablation led to shortening of the atrial fibrillation duration and increased dominant frequency gradient between right and left atrium. This suggested that interatrial septal conduction was filtered during atrial fibrillation. The ablation of bachmann’s bundle has possibility to suppress the atrial fibrillation cooperate with filtering effect of septal pathway.

Research Products

• [Journal Article] Restoration of sinus rhythm and atrial transport function after the maze procedure: U lesion set versus box lesion set. (2016)
  • Author(s): Nitta T, Ishii Y, Fujii M, Miyagi Y, Sakamoto S, Hiromoto A, Imura H.
  • Journal Title: J Thorac Cardiovasc Surg Volume: 151 Issue: 4 Pages: 1062-1069
  • DOI: 10.1016/j.jtcvs.2015.10.108
  • Peer Reviewed
• [Journal Article] Intraoperative cardiac mapping in the treatment of an infant congenital fibroma (2015)
  • Author(s): Sakamoto S, Shibata M, Murata H , Nitta T
  • Journal Title: Ann Thorac Surg. Volume: 99 Issue: 3 Pages: 1064-1066
  • DOI: 10.1016/j.athoracsur.2014.04.130
  • Peer Reviewed
• [Journal Article] Treatment of Wolff-Parkinson-White Syndrome with Thoracoscopic Surgery (2015)
  • Author(s): Motoko Tanoue, Shun-Ichiro Sakamoto, Yasushi Miyauchi, Jitsuo Usuda, Takashi Nitta
  • Journal Title: Ann Thorac Surg. Volume: 100 Issue: 1 Pages: 11-13
  • DOI: 10.1016/j.athoracsur.2015.04.081
  • Peer Reviewed
• [Journal Article] 冠動脈手術における心房細動治療：治療の意義と術式の選択 (2015)
  • Author(s): 坂本俊一郎
  • Journal Title: 冠疾患学会誌 Volume: 21 Pages: 246-252
  • NAID: 130005099387
  • Peer Reviewed