Basic research of valve opening-closing mechanism of ePTFE valve conduit used for right ventricular outflow tract (RVOT) reconstruction

• Project/Area Number: 25462151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kanto Gakuin University
• Principal Investigator: Akutsu Toshinosuke 関東学院大学, 理工学部, 教授 (90231852)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 人工心臓弁 / ePTFE弁 / PIV / 右室流出路再建 / 流体解析、PIV法 / PIV法

Outline of Final Research Achievements

Purpose of this research is to evaluate the leaflet and bulging sinus profile effect on valve opening-closing mechanism of ePTFE valve introduced by Prof. Yamagishi of Kyoto Prefectural Medical University. This valve has bulging sinus and good clinical record for Right Ventricular Out Flow Track Reconstruction. First year research was to evaluate bulging sinus size on valve opening area change using aorta as working model. Importance of vortex inside the bulging sinus and leaflet profile shape were observed and analyzed using Dynamic PIV flow field analysis. Second year research included more finely varied bulging sinus size aiming to broaden the scope of research. Final research was to execute experiment using live-sized ePTFE valve model and facility. Similar results were obtained using new model and facility. Results also clarified that movement of vortex inside the bulging sinus of new model behaved differently.

Research Products

• [Journal Article] 人工心臓弁の流体力学的評価と課題（機械的人工弁の歴史的進展と流れを視る流体力学的評価） (2015)
  • Author(s): 阿久津敏乃介
  • Journal Title: 設計工学 Volume: 50-3 Pages: 105-111
  • Peer Reviewed
• [Journal Article] 右室流出路再建に用いるePTFE弁の膨らみが流れ場と弁開閉に与える影響 (2015)
  • Author(s): 阿久津敏乃介、奥山晃一
  • Journal Title: 関東学院大学理工/建築・環境学会研究報告 Volume: 58 Pages: 1-6
  • NAID: 120006026137
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] INFLUENCE OF THE BULGING SINUS SIZE OF THE SIMULATED LIVESIZE EPTFE VALVE ON THE LEAFLET MOVEMENT OF THE VALVE CONDUIT (2015)
  • Author(s): T. Akutsu, H. Kakizaki
  • Journal Title: Abstracts from the XLII Congress of the European Society for Artificial Organs, Sep. 2-5, 2015, Lueuven, Belgium, IJAO Volume: 38-7
  • Peer Reviewed
• [Journal Article] High speed video study of the valve leaflet motion of the ePTFE valve conduit: influence of the bulging sinus size of the valve conduit on the valve opening area and flow field (2015)
  • Author(s): T. Akutsu, K. Okuyama
  • Journal Title: Proceedings of 14th World Congress in Mechanism and Machine Science, Taipei, Taiwan, 25-30 October, 2015 Volume: PS1-006 (CDROM)
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 大動脈の膨らみが弁開閉に与える影響 (2013)
  • Author(s): 阿久津敏乃介、大貫達也、奥山晃一
  • Journal Title: 関東学院大学理工/建築・環境学会研究報告 Volume: 57-1 Pages: 1-5
  • NAID: 120006026125
  • Peer Reviewed
• [Presentation] 右室流出路再建に用いるePTFE弁の膨らみおよび弁葉形状が流れ場に与える 影響（実寸法モデルによる弁開口面積の解析） (2016)
  • Author(s): 阿久津敏乃介，柿崎熙
  • Organizer: 第２８回バイオエンジニアリング講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-09
• [Presentation] 右室流出路再建に用いるePTFE弁の膨らみが弁の開閉に与える影響：実物大モデルによる検証 (2015)
  • Author(s): 阿久津敏乃介
  • Organizer: 第53回日本人工臓器学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-19
• [Presentation] Experimental Evaluation of the Prosthetic Heart Valve Flow (2015)
  • Author(s): Toshinosuke Akutsu
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-05-07
• [Presentation] Influence of rotational speed of Rotating Cylinder Electrode on convective layer vorticity strength and distribution: space distribution (2013)
  • Author(s): Toshinosuke Akutsu
  • Organizer: International Symposium on Highly-Controlled Nano- and Micro-Scale Functional Surface Structures for Frontier Smart Materials 2013
  • Place of Presentation: Yokohama
• [Presentation] Fundamental Study on the Sliding Wear Characteristics of Electroless Composite Plating (Ni-P-SiC) (2013)
  • Author(s): Masato Oomura, Toshihiro Miyatake, Kouichi Sekino, Toshinosuke Akutsu, Mitsuhiro Watanabe, Akira Teranishi, Takuya Ishida
  • Organizer: The Second International Conference on Materials, Energy and Environments (ICMEE)
  • Place of Presentation: Yokohama
• [Presentation] Influence of the Bulging sinus size of the aorta on the flow and leaflet movement of the aortic valve (2013)
  • Author(s): T. Akutsu, K. Okuyama and T. Oonuki
  • Organizer: The XL Congress of the ESAO
  • Place of Presentation: Glasgow, Scotland
• [Presentation] Hemodynamic Effect of an Atrial Contraction on Pulmonary Valve Functions in the Right Ventricular Simulator (2013)
  • Author(s): Yusuke Tsuboko, Yasuyuki Shiraishi, Satoshi Matsuo, Hidekatsu Miura, Akihiro Yamada, Takuya Shiga, Mohamed Omran Hashem, Takuya Ito, Kyosuke Sano, Yasunori Taira, Toshinosuke Akutsu, Zhonggang Feng, Mitsuo Umezu, Masaaki Yamagishi, Yoshikatsu Saiki, Tomoyuki Yambe
  • Organizer: 第51回日本人工臓器学会大会/第5回国際人工臓器学術大会
  • Place of Presentation: Yokohama
• [Presentation] Influence of rotational speed of Rotating Cylinder Electrode on vorticity strength and space distribution of convective flow field (2013)
  • Author(s): Toshinosuke Akutsu and Kouichi Sekino
  • Organizer: 1st International Conference on Surface Engineering (ICSE2013)
  • Place of Presentation: Busan, Korea
  • Invited
• [Presentation] Influence of the Bulging sinus size of the ePTFE valve conduit on the flow and opening area of the valve conduit (2013)
  • Author(s): K. Okuyama, and T. Akutsu
  • Organizer: The 15th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore
• [Presentation] Design of a Right Ventricular Simulator for the Evaluation of Artificial Pulmonary (2013)
  • Author(s): Y. Tsuboko, S. Matsuo, Y. Shiraishi, H. Miura, A. Yamada1, M.O. Hashem, T. Ito1, K. Sano1, Y., Taira1, T. Akutsu, Z. Feng6, M. Umezu, M. Yamagishi8, Y. Saiki, and T. Yambe
  • Organizer: The 15th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore
• [Presentation] Influence of Rotating Cylinder Electrode on convective layer vorticity and velocity strength and space distribution (2013)
  • Author(s): Toshinosuke Akutsu, and Kouichi Sekino
  • Organizer: The International Symposium on Materials Science and Surface Technology 2013
  • Place of Presentation: Yokohama