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The protective effects of adiponectin of CaCl2-induced aneurysm formation

Research Project

Project/Area Number 25462160
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionNagoya University

Principal Investigator

TOKUNAGA Seisaku  名古屋大学, 医学部附属病院, 医員 (70646520)

Co-Investigator(Kenkyū-buntansha) KOMORI KIMIHIRO  名古屋大学, 大学院医学系研究科, 教授 (40225587)
BANNO HIROSHI  名古屋大学, 医学部附属病院, 講師 (80584721)
KODAMA AKIO  名古屋大学, 医学部附属病院, 講師 (10528748)
MAEKAWA TAKASHI  名古屋大学, 医学部附属病院, 病院助教 (70732684)
SHIBATA REI  名古屋大学, 大学院医学系研究科, 寄附講座准教授 (70343689)
SUGIMOTO MASAYUKI  名古屋大学, 医学部附属病院, 病院助教 (00447814)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords動脈瘤、アディポネクチン / 大動脈瘤 / アディポネクチン / PPAR-ガンマ agonist / アディポサイトカイン
Outline of Final Research Achievements

Abdominal aortic aneurysm (AAA) is a feature of various vascular disorders including atherosclerosis and hypertension. A peroxisome proliferator-activated receptor-γ(PPARγ) ligand, pioglitazone is a relative new class of oral agent for the treatment of type 2 diabetes and insulin resistance. Pioglitazone has beneficial effects on endothelial function, hypertension and atherosclerosis. Here we investigated the effect of pioglitazone on AAA. The AAA model was induced by CaCl2 in male mice, and mice were treated with pioglitazone as food admixture at a concentration of 0.01%. Treatment of wild-type (WT) mice with pioglitazone attenuated CaCl2-induced aneurysm formation in mice. Pioglitazone also increased plasma adiponectin level in WT mice. However, adiponectin-deficient mice did not affect in CaCl2-induced aneurysm formation. These data provide direct evidence that pioglitazone protects against CaCl2-induced aneurysm formation via an adiponectin-independent mechanism.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (34 results)

All 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) (of which Invited: 14 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Relationship between the distal migration and length of the distal landing zone after endovascular aneurysm repair (EVAR).2016

    • Author(s)
      Ihara T, Komori K, Banno H, Kodama A, Yamamoto K, Sugimoto M
    • Journal Title

      Surg Today

      Volume: 46(1) Pages: 56-61

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hybrid versus open repair of aortic arch aneurysms: comparison of postoperative and mid-term outcomes with a propensity score-matching analysis.2016

    • Author(s)
      Tokuda Y, Oshima H, Narita Y, Abe T, Araki Y, Mutsuga M, Fujimoto K, Terazawa S, Yagami K, Ito H, Yamamoto K, Komori K, Usui A.
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 49(1) Issue: 1 Pages: 149-56

    • DOI

      10.1093/ejcts/ezv063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-time in vitro intravascular reconstruction and navigation for endovascular aortic stent grafting.2016

    • Author(s)
      Shi C, Tercero C, Wu X, Ikeda S, Komori K, Yamamoto K, Arai F, Fukuda T
    • Journal Title

      Int J Med Robot

      Volume: 印刷中 Issue: 4 Pages: 648-657

    • DOI

      10.1002/rcs.1736

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Active Catheter for Branched Stent Graft with Numerical Simulation under Pulsatile Flow.2016

    • Author(s)
      Kojima M, Carlos T, Yamamoto K, Ikeda S, Ooe K, Arai F, Komori K, Fukuda T
    • Journal Title

      日本ロボット学会誌

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 'through-and-through bowing technique' for antegrade thoracic endovascular aneurysm repair with total arch debranching: a technical note and the initial results.2016

    • Author(s)
      Yamamoto K, Komori K, Narita H, Morimae H, Tokuda Y, Araki Y, Oshima H, Usui A
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 印刷中 Issue: 4 Pages: 1264-1269

    • DOI

      10.1093/ejcts/ezv313

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of preoperative regular physical activity on postoperative course after open abdominal aortic aneurysm surgery.2016

    • Author(s)
      49.Hayashi K, Hirashiki A, Kodama A, Kobayashi K, Yasukawa Y, Shimizu M, Kondo T, Komori K, Murohara T
    • Journal Title

      Heart Vessels.

      Volume: 31 Issue: 4 Pages: 578-83

    • DOI

      10.1007/s00380-015-0644-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of notch signaling in the pathogenesis of Buerger's disease2014

    • Author(s)
      Hiroaki Tamai, Masayoshi Kobayashi, Kyousuke Takeshita, Akio Kodama, Hiroshi Banno, Hiroshi Narita, Kiyohito Yamamoto, Kimihiro Komori
    • Journal Title

      Surgey Today

      Volume: 44 Issue: 2 Pages: 307-313

    • DOI

      10.1007/s00595-013-0566-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of siRNA for vein failure2014

    • Author(s)
      Hiroki Miyachi, Shinji Mii, Atsushi Enomoto, Yoshiki Murakumo, Takuya Kato, Naoya Asai, Kimihiro Komori, Masahide Takahashi
    • Journal Title

      Journal of Vascular Surgery

      Volume: 60 Issue: 2 Pages: 479-489

    • DOI

      10.1016/j.jvs.2013.06.080

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model2014

    • Author(s)
      Takahashi N, Shibata R, Ouchi N, Sugimoto M, Murohara T, Komori K
    • Journal Title

      J Vasc Surg

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible roles of 5-HT in vein graft failure due to intimal hyperplasia 5-HT, nitric oxide and vein graft.2014

    • Author(s)
      Kodama A, Itoh T, Komori K
    • Journal Title

      Surg Today

      Volume: 44 Pages: 213-218

    • Related Report
      2013 Research-status Report
  • [Journal Article] ステントグラフトの中・長期成長2014

    • Author(s)
      古森公浩
    • Journal Title

      日本外科学会雑誌

      Volume: 115(2) Pages: 65-70

    • Related Report
      2013 Research-status Report
  • [Journal Article] Subclavian artery aneurysm in Marfan’s syndrome: Report of a case and review of literature.2014

    • Author(s)
      Morisaki K, Kobayashi M, Miyachi H, Maekawa T, Tamai H , Takahashi N, Watanabe Y, Morimae H, Ihara T, Kodama A, Narita H, Banno H, Yamamoto K, Komori K
    • Journal Title

      Annals of Vasc Surg

      Volume: in press

    • Related Report
      2013 Research-status Report
  • [Journal Article] Three-Dimensional Workstation is Useful for Measuring the Correct Size of Abdominal Aortic Aneurysm Diameters2013

    • Author(s)
      Ihara T, Komori K, Yamamoto K, Kobayashi M, Banno H, Kodama A
    • Journal Title

      Annals of Vascular Surgery

      Volume: 27(2) Issue: 2 Pages: 154-61

    • DOI

      10.1016/j.avsg.2012.03.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 当科における傍腎動脈腹部大動脈瘤に対する Open repair の成績2015

    • Author(s)
      坂野比呂志、徳永晴策、小山明男、田畑光紀、前川卓史、児玉章朗、成田裕司、山本清人、古森公浩
    • Organizer
      第115回日本外科学会定期学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腹部大動脈瘤に対するステントグラフト術後の中枢ネック角変化とmigration2014

    • Author(s)
      徳永晴策
    • Organizer
      第44回 日本心臓外科学会学術総会
    • Place of Presentation
      鶴屋ホール(熊本市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 破裂性腹部大動脈瘤治療の最前線2014

    • Author(s)
      古森公浩
    • Organizer
      第50回 日本腹部救急医学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] chimney technique併用EVAR術後、腎動脈損傷に対してコイル塞栓術を施行した1例2014

    • Author(s)
      徳永晴策、田畑光紀、小山明男、宮地紘樹、高橋範子、森前博文、杉本昌之、児玉章朗、成田裕司、山本清人、古森公浩
    • Organizer
      第22回 日本血管外科学会 東海・北陸地方会
    • Place of Presentation
      真宗大谷派金沢別院(金沢市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 血管病治療のパラダイムシフト ―大動脈瘤と末梢動脈閉塞症―2014

    • Author(s)
      古森公浩
    • Organizer
      日本医工学治療学会 第30回学術大会
    • Place of Presentation
      名鉄グランドホテル(名古屋市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Can pre op myocardial perfusion SPECT test predict late CV death after AAA repair.2014

    • Author(s)
      Komori K
    • Organizer
      Controversies and Updates in Vascular Surgery (CACVS)
    • Place of Presentation
      Paris(France)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 血管病治療のパラダイムシフト2013

    • Author(s)
      古森公浩
    • Organizer
      第113回日本外科学会定期学術総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 腎動脈再建を伴う腹部大動脈瘤手術2013

    • Author(s)
      古森公浩
    • Organizer
      第113回日本外科学会定期学術総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 腹部大動脈瘤に対するステントグラフト内挿術術後における中枢ネック角の経時的変化とmigration との関係2013

    • Author(s)
      徳永晴策
    • Organizer
      第113回日本外科学会定期学術総会
    • Place of Presentation
      マリンメッセ福岡(福岡市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] My Best Case or Worst Case (Vascular Surgery)2013

    • Author(s)
      古森公浩
    • Organizer
      第41回日本血管外科学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 末梢人工血管感染の経験2013

    • Author(s)
      徳永晴策、小山明男、宮地紘樹、高橋範子、渡辺芳雄、井原努、杉本昌之、児玉章朗、成田裕司、山本清人、古森公浩
    • Organizer
      第41回日本血管外科学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Periphral Arterial Disease(PAD)の検査とマネジメント2013

    • Author(s)
      古森公浩
    • Organizer
      第6回DAIICHI-SANKYO SYMPOSIUM FOR THROMBOSIS UPDATE
    • Place of Presentation
      山形国際ホテル(山形市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Peripheral arterial disease(PAD)治療の最前線2013

    • Author(s)
      古森公浩
    • Organizer
      第54回日本脈管学会総会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 末梢動脈疾患の診療2013

    • Author(s)
      古森公浩
    • Organizer
      第4回脈管専門医教育セッション
    • Place of Presentation
      ステーションコンフレンス東京(東京都千代田区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 静脈血栓塞栓症2013

    • Author(s)
      古森公浩
    • Organizer
      第75回日本臨床外科学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 今日の治療指針2014年版2014

    • Author(s)
      古森公浩、小室一成、奥山裕司、安東治郎、栗田隆志、青沼和隆、安部治彦、大蔵隆文、大屋祐輔、長谷部直幸、西野雅巳、大野実、安田聡、藤井謙司、高山守正、原和弘、高梨秀一郎、井上博、村川裕二、家坂義人
    • Total Pages
      2128
    • Publisher
      株式会社医学書院
    • Related Report
      2013 Research-status Report
  • [Book] エキスパートによる 消化器外科 静脈血栓塞栓症 診療指針2014

    • Author(s)
      古森公浩、左近賢人、黒岩政之、池田正孝、畑泰司、安井昌義、保田知生、榛沢和彦、中村真潮、井上壯一郎、竹内護、山本尚人、今野弘之、入野誠之、比企直樹、國崎主税、西村元一、板橋道朗、亀岡信悟、林洋毅
    • Total Pages
      189
    • Publisher
      株式会社南江堂
    • Related Report
      2013 Research-status Report
  • [Book] 大動脈外科の要点と盲点 第2版2013

    • Author(s)
      古森公浩、高本眞一、宮入剛、山内治雄、小野稔、志水秀行、安達秀雄、川原田修義、渡橋和政、井元清隆、加地修一郎、森﨑裕子、森﨑隆幸、西部俊哉、湊谷謙司、宮田哲郎、荻野均、山本晃太、師田哲郎、齋木佳克
    • Total Pages
      426
    • Publisher
      株式会社文光堂
    • Related Report
      2013 Research-status Report
  • [Remarks] 名古屋大学医学部附属病院 血管外科

    • URL

      http://www.med.nagoya-u.ac.jp/medical/6391/6429/kekkangekagaku.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 血管外科

    • URL

      http://www.vascsurg.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 名古屋大学大学院 医学系研究科 血管外科

    • URL

      http://www.vascsurg.jp/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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