Experimental analysis of continuous epidural cooling against spinal cord injury
Project/Area Number |
25462167
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular surgery
|
Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
Shimizu Hideyuki 慶應義塾大学, 医学部, 教授 (50226247)
Takaki Hidenobu 東京歯科大学, 歯学部, 助教 (20594683)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 胸腹部大動脈瘤 / 脊髄保護 / 硬膜外クーリング / 胸部大動脈瘤 |
Outline of Final Research Achievements |
Eighteen pigs underwent thoracic aortic double clamping for 35 minutes. These are divided into three groups, Gourp A(cooling temperature; 4℃), Group B (20℃), and Goup C(control). Mean time from aortic crossclamping to onset of MEP loss was significantly longer in group A and B than group C. Group A and group Bshowed significantly better neurologic function than that of group C. In group A and group B, motor neurons had a nearly normal appearance, with minimal eosinophilic change in the cytoplasm. Group C motor neurons showed acute necrotic changes. Degenerating neurons were swollen or shrunken.
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Report
(3 results)
Research Products
(59 results)
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[Presentation] Cases of acute aortic dissection after TEVAR2015
Author(s)
Yu Inaba, Akihiro Yoshitake, Takashi Hachiya, Kazuma Okamoto, Mikihiko Kudo, Hirofumi Haida, Hiroto Kitahara, Hideyuki Shimizu
Organizer
The23rd annual meeting of the Asian society for cardiovascular and thoracic surgery (ASCVTS)
Place of Presentation
香港(中国)
Year and Date
2015-05-11
Related Report
Int'l Joint Research
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[Presentation] Open surgical repair of aneurysms of the thoracoabdominal aorta using multidisciplinary approach for spinal cord protection.2013
Author(s)
Shimizu H, Yoshitake A, Mori A, Kawaguchi S, Yamabe K, Kawaguchi S, Takaki H, Ito T, Haida H, Hirano A, Taguchi S, Yozu R.
Organizer
ASCVTS2013
Place of Presentation
神戸インターナショナルカンファレンスセンター(神戸)
Related Report
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