A new non-invasive monitoring system for the pulmonary air leak flow and new treatment strategy for the pulmonary air leakage

• Project/Area Number: 25462171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: University of Tsukuba
• Principal Investigator: Sakai Mtisuaki 筑波大学, 医学医療系, 研究員 (60375508)
• Research Collaborator: IWAKAMI Kiyora 筑波大学, システム情報工学研究科, 大学院生 ; UEMATSU Hiroyuki ツジ電子株式会社, 代表取締役
• Project Period (FY): 2013-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エアリーク / 気漏 / 肺瘻 / 肺手術 / 気胸 / 胸腔 / ドレーン / 肺 / 肺切除術 / 手術 / モニタリング

Outline of Final Research Achievements

We developed a new non-invasive monitoring system for the pulmonary air leak flow.1)We could find three ways to measure the air leak flow quantitatively. Photographic analysis of the air bubbles with the high-speed camera could measure the flow with an error of less than 10%. The capacitance assay revealed that we could grasp an appearance of the air leak, when appropriate measurement condition. (3) Pressure fluctuation measuring and fast Fourier transform method showed that we could measure the air leak flow with an error less than 10%. 2) A prototype of air leak monitoring system was made. We found a method of data transmission synchronization for extending battery life. 3) We could not reach the clinical trial phase by the reason of the technical undevelopment. Pulmonary air leak in the chest drainage unit could be measured and monitored continuously using three differential methods. This new reusable technology could measure the accurate quantity of air leak.

Research Products

• [Journal Article] 複雑流路内間欠二相流における気相流量計測技術の開発 (2017)
  • Author(s): 岩上 聖， 金子 暁子，阿部 豊， 酒井 光昭
  • Journal Title: 日本混相流学会 混相流シンポジウム2017 講演論文集 Volume: -
  • NAID: 130006731388
• [Presentation] 胸腔ドレナージユニットにおけるエアリーク計測技術の開発 (2017)
  • Author(s): 岩上聖，金子暁子，阿部豊，酒井光昭
  • Organizer: 日本機械学会 関東支部第23期 総会・講演会
  • Place of Presentation: 東京理科大学 葛飾キャンパス（東京都）
  • Year and Date: 2017-03-17
• [Presentation] 気胸治療最適化に向けた医療用気相流量計測技術の開発 (2017)
  • Author(s): 岩上 聖， 金子 暁子，阿部 豊， 酒井 光昭
  • Organizer: 第33回ライフサポート学会
• [Presentation] 複雑流路内間欠二相流における気相流量計測技術の開発 (2017)
  • Author(s): 岩上 聖， 井上 裕三， 金子 暁子，阿部 豊，酒井 光昭
  • Organizer: 日本混相流学会 混相流シンポジウム2017
• [Presentation] Development of gas phase flow rate measurement technique on intermittent two-phase flow in a complex channel (2017)
  • Author(s): IWAKAMI Kiyora, KANEKO Akiko, ABE Yutaka, SAKAI Mitsuaki
  • Organizer: 10th International Symposium on Measurement Techniques for Multiphase Flow
  • Int'l Joint Research
• [Presentation] 胸腔ドレナージシステムにおけるエアリーク流量計測技術 (2017)
  • Author(s): 岩上聖，金子暁子，阿部豊，酒井光昭
  • Organizer: SATテクノロジーショーケース2017
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
• [Presentation] 肺切除後のエアリーク量を定量化できる非侵襲的肺瘻モニタリングシステムの開発
  • Author(s): 酒井光昭，山本 純，菊池慎二，後藤行延，鬼塚正孝，佐藤幸夫
  • Organizer: つくば医工連携フォーラム２０１４
  • Place of Presentation: 産業技術総合研究所つくば中央共同講堂（茨城県）
• [Patent(Industrial Property Rights)] 気体流量算出装置、気体流量測定システム、気体流量算出方法およびプログラム (2017)
  • Inventor(s): 阿部豊，金子暁子，岩上聖，酒井光昭
  • Industrial Property Rights Holder: 阿部豊，金子暁子，岩上聖，酒井光昭
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017