| Project/Area Number |
25462175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto Prefectural University of Medicine (2015-2016)
Osaka University (2013) |
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Principal Investigator |
Inoue Masayoshi 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10379232)
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| Co-Investigator(Kenkyū-buntansha) |
南 正人 大阪大学, 医学部附属病院, 准教授 (10240847)
奥村 明之進 大阪大学, 医学系研究科, 教授 (40252647)
澤端 章好 大阪大学, 医学系研究科, 招へい教授 (50403184)
舟木 壮一郎 大阪大学, 医学系研究科, 講師 (50464251)
中桐 伴行 大阪大学, 医学系研究科, 招へい教員 (70528710)
新谷 康 大阪大学, 医学系研究科, 准教授 (90572983)
川村 知裕 大阪大学, 医学系研究科, 助教 (30528675)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 肺癌 / PPAR-gamma / 上皮間葉移行 / PPARγ / 癌間質 |
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| Outline of Final Research Achievements |
PPAR-gamma, an intra-nuclear protein, has a potential role for anti-inflammation and anti-tumor effect. We assessed the anti-tumor role caused by the control of epithelial-mesenchymal transition using PPAR-gamma agonists in lung cancer. The epithelial-mesenchymal transition was slightly suppressed by tBHQ, an activator of Nrf2 which regulates PPAR-gamma expression in vitro. Additionally, pirfenidone, an anti-fibrotic agent, showed suppression both of epithelial-mesenchymal transition and cancer cell growth.
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