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Clarify of chemo-resistant mechanism in lung cancer targeting to epigenetic aberration

Research Project

Project/Area Number 25462182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionFukushima Medical University

Principal Investigator

SUZUKI HIROYUKI  福島県立医科大学, 医学部, 教授 (30322340)

Co-Investigator(Kenkyū-buntansha) MORI Tsutomu  福島県立医科大学, 看護学部, 准教授 (60244373)
Co-Investigator(Renkei-kenkyūsha) OSUGI Jun  福島県立医科大学, 医学部, 博士研究員 (40532528)
HASEGAWA Takeo  福島県立医科大学, 医学部, 助教 (80532530)
GOTOH Mitsukazu  福島県立医科大学, 医学部, 博士研究員 (50162160)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺癌 / 分子標的 / バイオマーカー / 肺外科 / エピジェネティクス / 化学療法
Outline of Final Research Achievements

UHRF family molecules were significantly highly expressed in squamous cell carcinoma as compare with that of adenocarcinoma in lung cancer. Furthermore, these molecules might be prognostic factor and involve to chemo-resistant mechanism. Novel biomarker named FAM83B were identified by our comprehensive gene expression analysis. FAM83B could be a diagnostic and prognostic biomarker in lung squamous cell cancer. Also, FAM83B was involved to cancer proliferation in EGFR wild type lung adenocarcinoma.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (33 results)

All 2016 2015 2014 2013

All Journal Article (16 results) (of which Peer Reviewed: 15 results,  Acknowledgement Compliant: 1 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] rognostic impact of clinical variables on surgically resected small-cell lung cancer: Results of a retrospective multicenter analysis (FIGHT002A and HOT1301A)2015

    • Author(s)
      Yokouchi H, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Fukuhara T, Takamura K, Kojima T, Harada T, Higuchi M, Matsuura Y, Honjo O, Minami Y, Watanabe N, Nishihara H, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
    • Journal Title

      Lung Cancer

      Volume: 90 Issue: 3 Pages: 548-53

    • DOI

      10.1016/j.lungcan.2015.10.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical significance of expanded Foxp3+ Helios- regulatory T cells in patients with non-small cell lung cancer2015

    • Author(s)
      Muto S, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Suzuki H, Gotoh M
    • Journal Title

      Int J Oncol

      Volume: 47 Issue: 6 Pages: 2082-2090

    • DOI

      10.3892/ijo.2015.3196

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FAM83B is a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma2015

    • Author(s)
      Okabe N, Ezaki J, Yamaura T, Muto S, Osugi J, Tamura H, Imai J, Ito E, Yanagisawa Y, Honma R, Gotoh M, Watanabe S, Waguri S, Suzuki H
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 3 Pages: 999-1006

    • DOI

      10.3892/ijo.2015.2817

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer2015

    • Author(s)
      Osugi J, Yamaura T, Muto S, Okabe N, Matsumura Y, Hoshino M, Higuchi M, Suzuki H, Gotoh M
    • Journal Title

      Lung Cancer

      Volume: 88 Issue: 3 Pages: 310-318

    • DOI

      10.1016/j.lungcan.2015.03.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma2015

    • Author(s)
      Osugi J, Kimura Y, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Muto S, Okabe N, Matsumura Y, Hasegawa T, Yonechi A, Hoshino M, Higuchi M, Shio Y, Suzuki H, Gotoh M
    • Journal Title

      Journal of Oncology

      Volume: 2015 Pages: 316745-316745

    • DOI

      10.1155/2015/316745

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Impact of FDG-PET in Surgically Treated Pathological Stage I Lung Adenocarcinoma2014

    • Author(s)
      Higuchi M, Hasegawa T, Osugi J, Suzuki H, Gotoh M.
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 20 Issue: 3 Pages: 185-191

    • DOI

      10.5761/atcs.oa.12.02219

    • NAID

      130003377890

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ANOMALOUS SYSTEMIC ARTERIAL SUPPLY TO THE BASAL SEGMENTS OF THE LUNG2013

    • Author(s)
      Higuchi M, Chida M, Muto A, Fukuhara M, Suzuki H, Gotoh M.
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 59 Issue: 2 Pages: 93-96

    • DOI

      10.5387/fms.59.93

    • NAID

      130003396122

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] WELL-DIFFERENTIATED FETAL ADENOCARCINOMA OF THE LUNG IN A 20-YEAR-OLD WOMAN2013

    • Author(s)
      Kanno R, Yamaura T, Higuchi M, Suzuki H, Ohishi A, Gotoh M.
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 59 Issue: 2 Pages: 89-92

    • DOI

      10.5387/fms.59.89

    • NAID

      130003396121

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent advances in immunotherapy for non-small-cell lung cancer.2013

    • Author(s)
      Suzuki H, Owada Y, Watanabe Y, Inoue T, Fukuharav M, Yamaura T, Mutoh S, Okabe N, Yaginuma H, Hasegawa T, Yonechi A, Ohsugi J, Hoshino M, Higuchi M, Shio Y, Gotoh M.
    • Journal Title

      Hum Vaccin Immunother.

      Volume: 10 Issue: 2 Pages: 352-357

    • DOI

      10.4161/hv.26919

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictive value of serum nitric oxide for bevacizumab response in patients with non-small cell lung cancer.2013

    • Author(s)
      Suzuki H, Ohsugi J, Hasegawa T, Yaginuma H, Okabe N, Muto S, Owada Y, Gotoh M.
    • Journal Title

      J Clin Oncol

      Volume: 31

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Extremely Elderly Patient with Lung Cancer Who Underwent Surgery2013

    • Author(s)
      Watanabe Y, Yonechi A, Inoue T, Kanno R, Oishi A, Suzuki H.
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 19 Issue: 5 Pages: 382-385

    • DOI

      10.5761/atcs.cr.13-00075

    • NAID

      130003387971

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer2013

    • Author(s)
      Suzuki H, Fukuhara M, Yamaura T, 他全16名
    • Journal Title

      J. Trans. Med

      Volume: 11(1) Issue: 1 Pages: 97-97

    • DOI

      10.1186/1479-5876-11-97

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current status of peptide vaccine for lung cancer.2013

    • Author(s)
      Suzuki H.
    • Journal Title

      Gan to Kagaku Ryoho.

      Volume: 40 Pages: 1009-1014

    • Related Report
      2013 Research-status Report
  • [Journal Article] A case of thymoma arising in a unilocular thymic cyst2013

    • Author(s)
      大杉 純, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 鈴木弘行.
    • Journal Title

      The Journal of the Japanese Association for Chest Surgery

      Volume: 27 Issue: 4 Pages: 522-527

    • DOI

      10.2995/jacsurg.27.522

    • NAID

      10031158808

    • ISSN
      0919-0945, 1881-4158
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Good症候群の1切除例.2013

    • Author(s)
      渡邊 譲, 岡部直行, 長谷川剛生, 大杉 純, 鈴木弘行.
    • Journal Title

      日本呼吸器外科学会雑誌.

      Volume: 27 Pages: 106-112

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 放射線治療が奏功した縦隔原発粘液線維肉腫の1例.2013

    • Author(s)
      渡邊 譲, 藤生浩一, 宮元秀昭, 鈴木弘行.
    • Journal Title

      日本呼吸器外科学会雑誌.

      Volume: 27 Pages: 766-771

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Functional analysis of family with sequence similarity 83, member B in lung adenocarcinoma2016

    • Author(s)
      Yamaura T, Suzuki H, et al
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      New Orleans, LO, USA
    • Year and Date
      2016-04-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 福島肺癌ゲノムプロジェクトの現状と展望2015

    • Author(s)
      鈴木弘行, 松村勇輝, 樋口光徳, 田中大輔, 菅野 亮, 七宮英晃, 今井順一, 伊藤恵美, 和栗 聡, 渡辺慎哉, 磯貝隆夫, 竹之下誠一, 後藤満一
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Efficiency and tolerability of nanoparticle albumin bound paclitaxel as a late phase chemotherapy for non-small cell lung cancer2015

    • Author(s)
      Higuchi M, Takagi H, Owada Y, Inoue T, Watanabe Y, Fukuhara M, Yamaura T, Muto S, Okabe N, Matsumura Y, Hasegawa T, Yonechi A, Osugi J, Hoshino M, Shio Y, Fujiu K, Kanno R, Ohishi A, Suzuki H.
    • Organizer
      The16th World Conference on Lung Cancer
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: A comparative analysis with adenocarcinoma and squamous cell carcinoma.2015

    • Author(s)
      Matsumura Y, Umemura S, Ishii G, Tsuta K, Matsumoto S, Aokage K, Hishida T, Yoshida J, Ohe Y, Suzuki H, Ochiai A, Goto K, Nagai K, Tsuchihara K.
    • Organizer
      AACR Annual Meeting 2015
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical feature of transcriptional factor Helios expression on regulatory T cells in patients with non-small cell lung cancer.2015

    • Author(s)
      Muto S, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Suzuki H, Gotoh M.
    • Organizer
      AACR Annual Meeting 2015
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-term outcome and current problems of VATS versus open lobectomy for clinical stage IA non-small cell lung cancer.2013

    • Author(s)
      Higuchi M, EndoG, Konno O, Kanno R, Ohishi A, Suzuki H.
    • Organizer
      The15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] Serum nitric oxide could be a predictor for the response of bevacizumab in patients with non-small cell lung cancer.2013

    • Author(s)
      Muto S, Suzuki H, Higuchi M, Osugi J, Hasegawa T, Yaginuma H, Okabe N, Yamaura T, Watanabe Y, Owada Y.
    • Organizer
      The15th World Conference on Lung Cancer
    • Place of Presentation
      Sydeny, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] FAM83B, a novel molecular target for lung squamous cell carcinoma.2013

    • Author(s)
      Okabe N, Suzuki H, Higuchi M, Osugi J, Hasegawa T, Muto S, Yamaura T, Watanabe Y, Waguri S, Watanabe S, Gotoh M.
    • Organizer
      1st International Conference of Federation of Asian Clinical Oncology
    • Place of Presentation
      Xiamen, China
    • Related Report
      2013 Research-status Report
  • [Presentation] FAM83B, a novel molecular target for lung squamous cell carcinoma.2013

    • Author(s)
      Okabe N, Suzuki H, Higuchi M, Osugi J, Hasegawa T, Muto S, Yamaura T, Watanabe Y, Owada Y, Waguri S, Watanabe S, Gotoh M.
    • Organizer
      The15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] 肺癌に対するプラチナ併用化学療法における制吐療法としての六君子湯の有用性.2013

    • Author(s)
      鈴木弘行, 大和田有紀, 渡邉 譲, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 米地 敦, 大杉 純, 星野実加, 樋口光徳, 塩  豊, 後藤満一.
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 当科における先進医療としての樹状細胞療法―肺癌における化学療法併用樹状細胞療法.2013

    • Author(s)
      鈴木弘行, 大和田有紀, 渡邉 譲, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 米地 敦, 大杉 純, 星野実加, 樋口光徳, 塩  豊, 後藤満一.
    • Organizer
      第38回日本外科系連合学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] プラチナ併用肺がん化学療法における六君子湯の食事量に及ぼす効果.2013

    • Author(s)
      鈴木弘行, 大和田有紀, 渡邉 譲, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 米地 敦, 大杉 純, 星野実加, 樋口光徳, 塩  豊, 後藤満一.
    • Organizer
      第38回日本外科系連合学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 免疫療法の進歩と課題2013

    • Author(s)
      鈴木弘行
    • Organizer
      NIRF Project Meeting
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Recent advances in imaging aided thoracic surgery.2013

    • Author(s)
      鈴木弘行
    • Organizer
      第1回International Aizu conference on biomedical informatics and technology (ACBIT 2013)
    • Place of Presentation
      会津若松
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] See-through typeヘッドマウントディスプレイを用いた術中画像支援の可能性.2013

    • Author(s)
      鈴木弘行,大杉 純, 長谷川剛生, 柳沼裕嗣, 岡部直行, 武藤哲史, 山浦 匠, 渡邉 譲, 井上卓哉, 大和田有紀, 後藤満一.
    • Organizer
      第66回日本胸部外科学会総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Book] PET Clinics2016

    • Author(s)
      Higuchi M, Suzuki H, Gotoh M
    • Total Pages
      94
    • Publisher
      ELSEVIER
    • Related Report
      2015 Annual Research Report
  • [Book] Immunotherapy for Cancer2015

    • Author(s)
      Suzuki H, et al
    • Total Pages
      358
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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