Clarify of chemo-resistant mechanism in lung cancer targeting to epigenetic aberration

• Project/Area Number: 25462182
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: SUZUKI HIROYUKI 福島県立医科大学, 医学部, 教授 (30322340)
• Co-Investigator(Kenkyū-buntansha): MORI Tsutomu 福島県立医科大学, 看護学部, 准教授 (60244373)
• Co-Investigator(Renkei-kenkyūsha): OSUGI Jun 福島県立医科大学, 医学部, 博士研究員 (40532528) ; HASEGAWA Takeo 福島県立医科大学, 医学部, 助教 (80532530) ; GOTOH Mitsukazu 福島県立医科大学, 医学部, 博士研究員 (50162160)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺癌 / 分子標的 / バイオマーカー / 肺外科 / エピジェネティクス / 化学療法

Outline of Final Research Achievements

UHRF family molecules were significantly highly expressed in squamous cell carcinoma as compare with that of adenocarcinoma in lung cancer. Furthermore, these molecules might be prognostic factor and involve to chemo-resistant mechanism. Novel biomarker named FAM83B were identified by our comprehensive gene expression analysis. FAM83B could be a diagnostic and prognostic biomarker in lung squamous cell cancer. Also, FAM83B was involved to cancer proliferation in EGFR wild type lung adenocarcinoma.

Research Products

• [Journal Article] rognostic impact of clinical variables on surgically resected small-cell lung cancer: Results of a retrospective multicenter analysis (FIGHT002A and HOT1301A) (2015)
  • Author(s): Yokouchi H, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Fukuhara T, Takamura K, Kojima T, Harada T, Higuchi M, Matsuura Y, Honjo O, Minami Y, Watanabe N, Nishihara H, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
  • Journal Title: Lung Cancer Volume: 90 Issue: 3 Pages: 548-53
  • DOI: 10.1016/j.lungcan.2015.10.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical significance of expanded Foxp3+ Helios- regulatory T cells in patients with non-small cell lung cancer (2015)
  • Author(s): Muto S, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Suzuki H, Gotoh M
  • Journal Title: Int J Oncol Volume: 47 Issue: 6 Pages: 2082-2090
  • DOI: 10.3892/ijo.2015.3196
  • Peer Reviewed / Open Access
• [Journal Article] FAM83B is a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma (2015)
  • Author(s): Okabe N, Ezaki J, Yamaura T, Muto S, Osugi J, Tamura H, Imai J, Ito E, Yanagisawa Y, Honma R, Gotoh M, Watanabe S, Waguri S, Suzuki H
  • Journal Title: Int J Oncol Volume: 46 Issue: 3 Pages: 999-1006
  • DOI: 10.3892/ijo.2015.2817
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of the combination of glucose transporter 1 and ATP citrate lyase in node-negative patients with non-small lung cancer (2015)
  • Author(s): Osugi J, Yamaura T, Muto S, Okabe N, Matsumura Y, Hoshino M, Higuchi M, Suzuki H, Gotoh M
  • Journal Title: Lung Cancer Volume: 88 Issue: 3 Pages: 310-318
  • DOI: 10.1016/j.lungcan.2015.03.004
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma (2015)
  • Author(s): Osugi J, Kimura Y, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Muto S, Okabe N, Matsumura Y, Hasegawa T, Yonechi A, Hoshino M, Higuchi M, Shio Y, Suzuki H, Gotoh M
  • Journal Title: Journal of Oncology Volume: 2015 Pages: 316745-316745
  • DOI: 10.1155/2015/316745
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of FDG-PET in Surgically Treated Pathological Stage I Lung Adenocarcinoma (2014)
  • Author(s): Higuchi M, Hasegawa T, Osugi J, Suzuki H, Gotoh M.
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: 20 Issue: 3 Pages: 185-191
  • DOI: 10.5761/atcs.oa.12.02219
  • NAID: 130003377890
  • ISSN: 1341-1098, 2186-1005
  • Peer Reviewed
• [Journal Article] ANOMALOUS SYSTEMIC ARTERIAL SUPPLY TO THE BASAL SEGMENTS OF THE LUNG (2013)
  • Author(s): Higuchi M, Chida M, Muto A, Fukuhara M, Suzuki H, Gotoh M.
  • Journal Title: FUKUSHIMA JOURNAL OF MEDICAL SCIENCE Volume: 59 Issue: 2 Pages: 93-96
  • DOI: 10.5387/fms.59.93
  • NAID: 130003396122
  • ISSN: 0016-2590, 2185-4610
  • Peer Reviewed
• [Journal Article] WELL-DIFFERENTIATED FETAL ADENOCARCINOMA OF THE LUNG IN A 20-YEAR-OLD WOMAN (2013)
  • Author(s): Kanno R, Yamaura T, Higuchi M, Suzuki H, Ohishi A, Gotoh M.
  • Journal Title: FUKUSHIMA JOURNAL OF MEDICAL SCIENCE Volume: 59 Issue: 2 Pages: 89-92
  • DOI: 10.5387/fms.59.89
  • NAID: 130003396121
  • ISSN: 0016-2590, 2185-4610
  • Peer Reviewed
• [Journal Article] Recent advances in immunotherapy for non-small-cell lung cancer. (2013)
  • Author(s): Suzuki H, Owada Y, Watanabe Y, Inoue T, Fukuharav M, Yamaura T, Mutoh S, Okabe N, Yaginuma H, Hasegawa T, Yonechi A, Ohsugi J, Hoshino M, Higuchi M, Shio Y, Gotoh M.
  • Journal Title: Hum Vaccin Immunother. Volume: 10 Issue: 2 Pages: 352-357
  • DOI: 10.4161/hv.26919
  • Peer Reviewed
• [Journal Article] Predictive value of serum nitric oxide for bevacizumab response in patients with non-small cell lung cancer. (2013)
  • Author(s): Suzuki H, Ohsugi J, Hasegawa T, Yaginuma H, Okabe N, Muto S, Owada Y, Gotoh M.
  • Journal Title: J Clin Oncol Volume: 31
  • Peer Reviewed
• [Journal Article] An Extremely Elderly Patient with Lung Cancer Who Underwent Surgery (2013)
  • Author(s): Watanabe Y, Yonechi A, Inoue T, Kanno R, Oishi A, Suzuki H.
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: 19 Issue: 5 Pages: 382-385
  • DOI: 10.5761/atcs.cr.13-00075
  • NAID: 130003387971
  • ISSN: 1341-1098, 2186-1005
  • Peer Reviewed
• [Journal Article] Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer (2013)
  • Author(s): Suzuki H, Fukuhara M, Yamaura T, 他全16名
  • Journal Title: J. Trans. Med Volume: 11(1) Issue: 1 Pages: 97-97
  • DOI: 10.1186/1479-5876-11-97
  • Peer Reviewed
• [Journal Article] Current status of peptide vaccine for lung cancer. (2013)
  • Author(s): Suzuki H.
  • Journal Title: Gan to Kagaku Ryoho. Volume: 40 Pages: 1009-1014
• [Journal Article] A case of thymoma arising in a unilocular thymic cyst (2013)
  • Author(s): 大杉 純, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 鈴木弘行.
  • Journal Title: The Journal of the Japanese Association for Chest Surgery Volume: 27 Issue: 4 Pages: 522-527
  • DOI: 10.2995/jacsurg.27.522
  • NAID: 10031158808
  • ISSN: 0919-0945, 1881-4158
  • Peer Reviewed
• [Journal Article] Good症候群の１切除例. (2013)
  • Author(s): 渡邊 譲, 岡部直行, 長谷川剛生, 大杉 純, 鈴木弘行.
  • Journal Title: 日本呼吸器外科学会雑誌. Volume: 27 Pages: 106-112
  • Peer Reviewed
• [Journal Article] 放射線治療が奏功した縦隔原発粘液線維肉腫の１例. (2013)
  • Author(s): 渡邊 譲, 藤生浩一, 宮元秀昭, 鈴木弘行.
  • Journal Title: 日本呼吸器外科学会雑誌. Volume: 27 Pages: 766-771
  • Peer Reviewed
• [Presentation] Functional analysis of family with sequence similarity 83, member B in lung adenocarcinoma (2016)
  • Author(s): Yamaura T, Suzuki H, et al
  • Organizer: AACR Annual Meeting 2016
  • Place of Presentation: New Orleans, LO, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] 福島肺癌ゲノムプロジェクトの現状と展望 (2015)
  • Author(s): 鈴木弘行, 松村勇輝, 樋口光徳, 田中大輔, 菅野 亮, 七宮英晃, 今井順一, 伊藤恵美, 和栗 聡, 渡辺慎哉, 磯貝隆夫, 竹之下誠一, 後藤満一
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2015-10-30
• [Presentation] Efficiency and tolerability of nanoparticle albumin bound paclitaxel as a late phase chemotherapy for non-small cell lung cancer (2015)
  • Author(s): Higuchi M, Takagi H, Owada Y, Inoue T, Watanabe Y, Fukuhara M, Yamaura T, Muto S, Okabe N, Matsumura Y, Hasegawa T, Yonechi A, Osugi J, Hoshino M, Shio Y, Fujiu K, Kanno R, Ohishi A, Suzuki H.
  • Organizer: The16th World Conference on Lung Cancer
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: A comparative analysis with adenocarcinoma and squamous cell carcinoma. (2015)
  • Author(s): Matsumura Y, Umemura S, Ishii G, Tsuta K, Matsumoto S, Aokage K, Hishida T, Yoshida J, Ohe Y, Suzuki H, Ochiai A, Goto K, Nagai K, Tsuchihara K.
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Clinical feature of transcriptional factor Helios expression on regulatory T cells in patients with non-small cell lung cancer. (2015)
  • Author(s): Muto S, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Suzuki H, Gotoh M.
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Long-term outcome and current problems of VATS versus open lobectomy for clinical stage IA non-small cell lung cancer. (2013)
  • Author(s): Higuchi M, EndoG, Konno O, Kanno R, Ohishi A, Suzuki H.
  • Organizer: The15th World Conference on Lung Cancer
  • Place of Presentation: Sydney, Australia
• [Presentation] Serum nitric oxide could be a predictor for the response of bevacizumab in patients with non-small cell lung cancer. (2013)
  • Author(s): Muto S, Suzuki H, Higuchi M, Osugi J, Hasegawa T, Yaginuma H, Okabe N, Yamaura T, Watanabe Y, Owada Y.
  • Organizer: The15th World Conference on Lung Cancer
  • Place of Presentation: Sydeny, Australia
• [Presentation] FAM83B, a novel molecular target for lung squamous cell carcinoma. (2013)
  • Author(s): Okabe N, Suzuki H, Higuchi M, Osugi J, Hasegawa T, Muto S, Yamaura T, Watanabe Y, Waguri S, Watanabe S, Gotoh M.
  • Organizer: 1st International Conference of Federation of Asian Clinical Oncology
  • Place of Presentation: Xiamen, China
• [Presentation] FAM83B, a novel molecular target for lung squamous cell carcinoma. (2013)
  • Author(s): Okabe N, Suzuki H, Higuchi M, Osugi J, Hasegawa T, Muto S, Yamaura T, Watanabe Y, Owada Y, Waguri S, Watanabe S, Gotoh M.
  • Organizer: The15th World Conference on Lung Cancer
  • Place of Presentation: Sydney, Australia
• [Presentation] 肺癌に対するプラチナ併用化学療法における制吐療法としての六君子湯の有用性. (2013)
  • Author(s): 鈴木弘行, 大和田有紀, 渡邉 譲, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 米地 敦, 大杉 純, 星野実加, 樋口光徳, 塩 豊, 後藤満一.
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] 当科における先進医療としての樹状細胞療法―肺癌における化学療法併用樹状細胞療法. (2013)
  • Author(s): 鈴木弘行, 大和田有紀, 渡邉 譲, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 米地 敦, 大杉 純, 星野実加, 樋口光徳, 塩 豊, 後藤満一.
  • Organizer: 第38回日本外科系連合学会総会
  • Place of Presentation: 東京
• [Presentation] プラチナ併用肺がん化学療法における六君子湯の食事量に及ぼす効果. (2013)
  • Author(s): 鈴木弘行, 大和田有紀, 渡邉 譲, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 柳沼裕嗣, 長谷川剛生, 米地 敦, 大杉 純, 星野実加, 樋口光徳, 塩 豊, 後藤満一.
  • Organizer: 第38回日本外科系連合学会総会
  • Place of Presentation: 東京
• [Presentation] 免疫療法の進歩と課題 (2013)
  • Author(s): 鈴木弘行
  • Organizer: NIRF Project Meeting
  • Place of Presentation: 東京
  • Invited
• [Presentation] Recent advances in imaging aided thoracic surgery. (2013)
  • Author(s): 鈴木弘行
  • Organizer: 第1回International Aizu conference on biomedical informatics and technology (ACBIT 2013)
  • Place of Presentation: 会津若松
  • Invited
• [Presentation] See-through typeヘッドマウントディスプレイを用いた術中画像支援の可能性. (2013)
  • Author(s): 鈴木弘行,大杉 純, 長谷川剛生, 柳沼裕嗣, 岡部直行, 武藤哲史, 山浦 匠, 渡邉 譲, 井上卓哉, 大和田有紀, 後藤満一.
  • Organizer: 第66回日本胸部外科学会総会
  • Place of Presentation: 仙台
• [Book] PET Clinics (2016)
  • Author(s): Higuchi M, Suzuki H, Gotoh M
  • Total Pages: 94
  • Publisher: ELSEVIER
• [Book] Immunotherapy for Cancer (2015)
  • Author(s): Suzuki H, et al
  • Total Pages: 358
  • Publisher: Springer