Study of Malignancy for Pulmonary and Mediastinal Lesions by MR Diffusion-Weighted Imaging and Angiogenesis / Genetic Analysis

• Project/Area Number: 25462186
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kanazawa Medical University
• Principal Investigator: USUDA Katsuo 金沢医科大学, 医学部, 教授 (00324046)
• Co-Investigator(Kenkyū-buntansha): UEDA Yoshimichi 金沢医科大学, 医学部, 教授 (50271375) ; MATOBA Munetaka 金沢医科大学, 医学部, 教授 (90288308) ; SAGAWA Motoyasu 金沢医科大学, 医学部, 教授 (70292274)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: MR拡散強調画像 / PET-CT / 肺癌 / 縦隔腫瘍 / 画像診断 / 肺腫瘤状陰影 / 肺門縦隔リンパ節 / 診断精度 / EGFR遺伝子変異 / ground glass opacity / 拡散強調画像

Outline of Final Research Achievements

Diffusion-weighted imaging (DWI) could detect significantly smaller metastatic lymph nodes than by PET-CT. It was a reason why DWI presented a significantly higher accuracy than that of PET-CT. DWI had more potential than PET-CT in assessing pulmonary lesions. For recurrence or metastasis from lung cancer, the detection rate of DWI was significantly higher than that of CT, but not significantly higher than that of PET-CT. For mediastinal tumors, the sensitivity (100%) of DWI is not significantly higher than that (93.8%) of PET-CT, the specificity (83.3%) of DWI was not significantly higher than that (66.7%) of PET-CT, and the accuracy (92.9%) of DWI was not significantly higher than that (82.1%) of PET-CT. For multiple hilar and mediastinal lymph nodes (MHMLN) with FDG accumulation, specificity and accuracy of DWI were significantly higher than those of PET-CT. Evaluation by DWI for patients with MHMLN with FDG accumulation was useful for distinguishing benignity and malignancy.

Research Products

• [Journal Article] Diagnostic Performance of Diffusion Weighted Imaging for Multiple Hilar and Mediastinal Lymph Nodes with FDG Accumulation. (2015)
  • Author(s): Usuda K, Maeda S, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Watanabe N, Tonami H, Ueda Y, Sagawa M
  • Journal Title: Asian Pac. J. Cancer Prev Volume: 16 Pages: 6401-6406
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diffusion Weighted Imaging Can Distinguish Benign from Malignant Mediastinal Tumors and Mass Lesions. Comparison with Positron Emission Tomography. (2015)
  • Author(s): Usuda K, Maeda S, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Watanabe N,, Tonami H, Ueda Y, Sagawa M,
  • Journal Title: Asian Pac. J. Cancer Prev Volume: 16 Pages: 6469-6475
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationships between EGFR mutation status of lung cancer and preoperative factors - Are they predictive? (2014)
  • Author(s): Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Taniguchi M, Tonami H, Ueda Y, Sakuma T.
  • Journal Title: Asian Pac J Cancer Prev. Volume: 15 (2) Issue: 2 Pages: 657-662
  • DOI: 10.7314/apjcp.2014.15.2.657
  • Peer Reviewed
• [Presentation] MR拡散強調画像による縦隔腫瘍の評価．特に胸腺上皮性腫瘍の鑑別の有用性について (2015)
  • Author(s): 薄田勝男、本野 望、田中 良、町田雄一郎、前田寿美子、的場宗孝、利波久雄、佐川元保.
  • Organizer: 第56回日本肺癌学会学術総会
  • Place of Presentation: パシフィコ横浜 （神奈川県横浜市）
  • Year and Date: 2015-11-26
• [Presentation] 悪性胸膜中皮腫に対するMR拡散強調画像による画像診断の有用性 (2015)
  • Author(s): 薄田勝男, 本野 望, 上野正克, 田中 良, 町田雄一郎, 前田寿美子,的場 宗孝, 佐川元保
  • Organizer: 第32回日本呼吸器外科学会総会
  • Place of Presentation: サンポートホール高松（香川県高松市）
  • Year and Date: 2015-05-14
• [Presentation] Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography. (2015)
  • Author(s): Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Maeda S, Matoba M, Kuginuki Y, Taniguchi M, Tonami H, Ueda Y, Sakuma T.
  • Organizer: European Lung cancer Conferrence 2015
  • Place of Presentation: Geneva, Switzerland.
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] Advantages of diffusion-weighted imaging over positron emission tomography-computed tomography in assessment of hilar and mediastinal lymph node in lung cancer. (2013)
  • Author(s): Katsuo Usuda, Motoyasu Sagawa, Nozomu Motono, Masakatsu Ueno, Makoto Tanaka, Yuichiro Machida, Munetaka Matoba, Yasuaki Kuginuki, Mitsuru Taniguchi, Yoshimichi Ueda, Tsutomu Sakuma
  • Organizer: 18 th World Congress on advances in oncology
  • Place of Presentation: Creta Maris Hotel (Crete, Greece)
• [Presentation] 肺癌再発病変に対するMR拡散強調画像の有用性とその画像の特徴 (2013)
  • Author(s): 薄田勝男, 本野 望, 上野正克, 田中 良, 町田雄一郎, 佐川元保, 的場宗孝, 佐久間勉
  • Organizer: 第30回日本呼吸器外科学会総会
  • Place of Presentation: 名古屋国際会議場 (愛知県名古屋市)