| Project/Area Number |
25462190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Fumihiro 産業医科大学, 医学部, 教授 (10283673)
WADA Hiromi 京都大学, 医学研究科, 名誉教授 (30111975)
SABE Hisataka 北海道大学, 医学(系)研究科(研究院), 教授 (40187282)
URAMOTO Hidetaka 産業医科大学, 医学部, 准教授 (90389445)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胸部悪性腫瘍 / p-EGFR / GEP100 / Arf6 / 予後 |
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| Outline of Final Research Achievements |
To overcome resistance to treatment in lung cancer, it is necessary to reveal biological factors contributing to its progression. The aim of the current study is to reveal the roles of the EGFR-GEP100-Arf6 axis in controlling migration and adhesion of tumor cells and to assess its clinical applications. First, we immunohistochemically examined expression of these molecules in resected lung adenocarcinoma cases (n=182), and showed that expression of these molecules was significantly associated with poor prognosis, suggesting that the EGFR-GEP100-Arf6 axis plays important roles in invasion and metastasis that are responsible to poor prognosis. Next, we examined biological factors contributing to development and progression of malignant mesothelioma, and revealed that some EMT-related factors were significant prognostic factors that can be potentially useful clinical marker in malignant mesothelioma.
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