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The strategies to overcome resistance to ALK inhibitor in lung cancer.

Research Project

Project/Area Number 25462193
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionChiba Cancer Center (Research Institute)

Principal Investigator

Yokoi Sana  千葉県がんセンター(研究所), がんゲノムセンター, 部長 (30372452)

Co-Investigator(Kenkyū-buntansha) Iizasa Toshihiko  千葉県がんセンター, 呼吸器外科, 部長 (10272303)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肺癌
Outline of Final Research Achievements

Anaplastic lymphoma kinase (ALK) which is one of the receptor tyrosine kinase is activated by chromosomal translocation and causes lung cancer (ALK lung cancer). ALK inhibitor shows remarkable effect for ALK lung cancer. However, ALK lung cancer becomes tolerance to ALK inhibitor in short time. To find a new therapeutic target for ALK lung cancer, the genomic abnormality was analyzed. As a result, we found a putative candidate gene which is decreased expression in ALK lung cancer by genomic deletion or DNA methylation in promoter region. A forced expression of this gene leads to the growth retardation in lung cancer cell line with ALK translocation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results) Book (1 results)

  • [Journal Article] High CC chemokine receptor 7 expression improves postoperative prognosis of lung adenocarcinoma patients.2013

    • Author(s)
      Itakura M, Terashima Y, Shingyoji M, Yokoi S, Ohira M, Kageyama H, Matui Y, Yoshida Y, Ashinuma H, Moriya Y, Tamura H, Harigaya K, Matushima K, Iizasa T, Nakagawara A, Kimura H.
    • Journal Title

      Br J Cancer.

      Volume: 109 Pages: 1100-1108

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma.2013

    • Author(s)
      Iuchi T, Shingyoji M, Sakaida T, Hatano K, Nagano O, Itakura M, Kageyama H, Yokoi S, Hasegawa Y, Kawasaki K, Iizasa T.
    • Journal Title

      Lung Cancer

      Volume: 82 Pages: 282-287

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 染色体転座により発現制御をされるALK関連分子の解析2015

    • Author(s)
      横井左奈、兼松宗太郎、近藤仁美、末永雄介、木村秀樹、飯笹俊彦
    • Organizer
      第62回日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Frequent somatic mutations in neuroendocrine differentiation-related pathways in SCLC-transformed lung adenocarcinomas2015

    • Author(s)
      Yusyke Suenaga, Masato shingyoji, Mamoru Kato, Isao Kurosaka, Miki Ohira, Tishihiko Iizasa, Hiroki Nagase, Sana Yokoi
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 染色体転座に伴ってゲノム・エピゲノム制御を受けるALK関連分子の解析2015

    • Author(s)
      横井左奈、兼松宗太郎、近藤仁美、大塚紀子、末永雄介、木村秀樹、飯笹俊彦
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Frequent somatic mutations in neuroendocrine differentiation-related pathways in SCLC-transformed lung adenocarcinomas2015

    • Author(s)
      Yusyke Suenaga,Masato shingyoji,Mamoru Kato,Isao Kurosaka,Miki Ohira,Tishihiko Iizasa,Hiroki Nagase,Sana Yokoi
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] EBUS-TBNAを利用した小細胞肺癌におけるTopoisomeraseの発現に関する検討2015

    • Author(s)
      新行内雅斗、芦沼宏典、吉田泰司、石橋史博、田村創、松井由紀子、守屋康充、飯笹俊彦、横井左奈、中島崇裕、関根郁夫
    • Organizer
      日本呼吸器内視鏡学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Novel cancer related gene in ALK-positive lung cancer2013

    • Author(s)
      横井左奈、夏恩迪、木村秀樹、中村友紀、大平美紀、影山肇、池部大、杉山孝弘、伊丹真紀子、永瀬浩喜、飯笹俊彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Somatic mutation search using next-gen sequencing approach2013

    • Author(s)
      影山肇、丸喜明、中村由紀、大平美紀、横井左奈、越川信子、片山稔、永瀬浩喜
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Targeted exome sequencing of cancer related genes in lung cancer2013

    • Author(s)
      飯笹俊彦、横井左奈、守屋康充、丸喜明、大平美紀、影山肇、中村友紀、近藤仁美、夏恩迪、新行内雅斗、板倉明司、伊丹真紀子、吉野一郎、永瀬浩喜
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Whole-exome sequencing of human non-small cell lung cancers and matched metastases to analyze metastatic driver mutations2013

    • Author(s)
      Wataru Shintani, Sumitaka Hase, Kengo Sato, Toshihiko Iizasa, Sana Yokoi, and Yasubumi Sakakibara
    • Organizer
      EMBL Conference Cancer Genomics
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] ALK融合遺伝子陽性肺癌におけるゲノム解析2013

    • Author(s)
      橫井 左奈,  木村 秀樹, 夏 恩迪,影山 肇、 大平 美紀, 池部 大, 杉山 孝弘、 伊丹 真紀子, 飯笹 俊彦
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Book] 遺伝医学MOOK別冊 今さら聞けない遺伝医学 「がんのゲノム医学入門」2014

    • Author(s)
      横井 左奈
    • Total Pages
      193
    • Publisher
      株式会社 メディカルドゥ
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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