| Project/Area Number |
25462194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Toneyama National Hospital |
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Principal Investigator |
Susaki Yoshiyuki 独立行政法人国立病院機構刀根山病院(臨床研究部), その他部局等, 研究員 (10528649)
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| Co-Investigator(Kenkyū-buntansha) |
Okumura Meinoshin 大阪大学, 医学系研究科, 教授 (40252647)
Minami Masato 大阪大学, 医学部附属病院, 准教授 (10240847)
Inoue Masayoshi 京都府立大学, 医学系研究科, 教授 (10379232)
Shintani Yasushi 大阪大学, 医学系研究科, 准教授 (90572983)
Nakagiri Tomoyuki 大阪大学, 医学系研究科, 研究員 (70528710)
澤端 章好 大阪大学, 医学(系)研究科(研究院), 教授 (50403184)
舟木 壮一郎 大阪大学, 医学(系)研究科(研究院), 助教 (50464251)
川村 知裕 大阪大学, 医学(系)研究科(研究院), 助教 (30528675)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | podoplanin / 胸腺癌 / 胸腺腫 / CTOS |
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| Outline of Final Research Achievements |
Podoplanin expression was examined immunohistochmically in invasive thymomas and thymic carcinomas.Regarding disease-free survival,podoplanin-positive cases had significantly poorer prognsis than podolanin-negative cases. Podoplanin expession was obseved in disseminated lesions frequently.These data indicated that podoplanin was associated with the progress of invasion of thymomas. We established the thymic carcinoma cell line, and clarify podoplanin expression in thymic carcinoma cells correlate with Epithelial Mesenchymal transition.
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