The establishment of multimodal therapy of thymic epithelial tumors with podoplanin expression

Research Project

Project/Area Number	25462194
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Respiratory surgery
Research Institution	Toneyama National Hospital
Principal Investigator	Susaki Yoshiyuki 独立行政法人国立病院機構刀根山病院(臨床研究部), その他部局等, 研究員 (10528649)
Co-Investigator(Kenkyū-buntansha)	Okumura Meinoshin 大阪大学, 医学系研究科, 教授 (40252647) Minami Masato 大阪大学, 医学部附属病院, 准教授 (10240847) Inoue Masayoshi 京都府立大学, 医学系研究科, 教授 (10379232) Shintani Yasushi 大阪大学, 医学系研究科, 准教授 (90572983) Nakagiri Tomoyuki 大阪大学, 医学系研究科, 研究員 (70528710) 澤端章好大阪大学, 医学(系)研究科(研究院), 教授 (50403184) 舟木壮一郎大阪大学, 医学(系)研究科(研究院), 助教 (50464251) 川村知裕大阪大学, 医学(系)研究科(研究院), 助教 (30528675)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	podoplanin / 胸腺癌 / 胸腺腫 / CTOS
Outline of Final Research Achievements	Podoplanin expression was examined immunohistochmically in invasive thymomas and thymic carcinomas.Regarding disease-free survival,podoplanin-positive cases had significantly poorer prognsis than podolanin-negative cases. Podoplanin expession was obseved in disseminated lesions frequently.These data indicated that podoplanin was associated with the progress of invasion of thymomas. We established the thymic carcinoma cell line, and clarify podoplanin expression in thymic carcinoma cells correlate with Epithelial Mesenchymal transition.