Metabolome analysis of hypoxia mechanism in malignant pleural mesothelioma

• Project/Area Number: 25462196
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Hiroshima University
• Principal Investigator: Miyata Yoshihiro 広島大学, 原爆放射線医科学研究所, 准教授 (50397965)
• Co-Investigator(Kenkyū-buntansha): OKADA MORIHITO 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 悪性胸膜中皮腫 / 低酸素 / メタボローム / HIF 1α / glucose transporter 1 / PET

Outline of Final Research Achievements

We hypothesized that hypoxia induced by tumor proliferation may play an important role in malignant pleural mesothelioma (MPM). We evaluate the relevance of several biomarkers to predict the prognosis of MPM. There was no correlation of HIF1α and GLUT1 expressions with clinical outcome. .DHFR expression significantly associated with survival after induction chemotherapy followed by surgery. When biopsy and surgeries were compared per patient, merlin expression levels are the same before and after chemotherapy (R2=0.5126). Merlin low patients (34%) had significantly good prognosis. These molecules could be good predictors to decide the treatment strategy for MPM.

Research Products

• [Journal Article] Use of Anti-Noxa Antibody for Differential Diagnosis between Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia (2016)
  • Author(s): Kushitani K, Amatya VJ, Mawas AS, Miyata Y, Okada M, Takeshima Y
  • Journal Title: Pathobiology Volume: 83 Issue: 1 Pages: 33-40
  • DOI: 10.1159/000442092
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between [18F]-fluoro-2-deoxyglucose uptake and expressions of hypoxia-induced factor 1α and glucose transporter 1 in non-small cell lung cancer (2015)
  • Author(s): Takaoki Furukawa
  • Journal Title: Ｊａｐａｎｅｓｅ ｊｏｕｒｎａｌ ｏｆ ｃｌｉｎｉｃａｌ ｏｎｃｏｌｏｇｙ Volume: 45 (12) Pages: 1154-1161
  • DOI: 10.1093/jjco/hyv138
  • Peer Reviewed
• [Presentation] FDG uptake on PET correlates with IASLC/ATS/ERS histologic subtypes and prognosis of clinical stage IA lung adenocarcinoma (2015)
  • Author(s): Yoshihiro Miyata, Takeshi. Mimura, Takaoki Furukawa, Yasuhiro. Tsutani, Takahiro. Mimae, Tomoharu. Yoshiya, Masaoki. Ito, Yuichiro. Kai, Atsushi. Kagimoto Norifumi Tsubokawa, H. Nakayama* and Morihito Okada
  • Organizer: 29thEACTS
  • Place of Presentation: アムステルダム（オランダ）
  • Year and Date: 2015-10-03
  • Int'l Joint Research
• [Presentation] 悪性胸膜中皮腫に対する胸膜切除／肺剥皮術の検討 (2014)
  • Author(s): 宮田義浩
  • Organizer: 日本肺癌学会
  • Place of Presentation: 東京