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Development of evaluation methods of the real-time cerebral blood flow in the internal carotid artery occlusion

Research Project

Project/Area Number 25462204
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionTohoku University

Principal Investigator

Sato Kenichi  東北大学, 医学(系)研究科(研究院), 非常勤講師 (90634973)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Atsuhiro  東北大学, 大学病院, 助教 (10447162)
WASHIO Toshikatsu  国立研究開発法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (40358370)
ARAHUNE Tatsuhiko  東京電気大学, 理工学部, 助教 (50376597)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳血流 / 大脳半球循環時間 / クモ膜下出血 / 脳血管攣縮 / 遅発性脳虚血 / 内頚動脈閉塞 / 後方視的研究 / 英文雑誌報告 / 学会発表
Outline of Final Research Achievements

Balloon occlusion test has been used for the evaluation of the tolerance against unilateral internal carotid artery occlusion. The conventional balloon occlusion test has required the measurement of the cerebral blood flow and clinical condition during the occlusion of the internal carotid artery. In this research, we elucidated a strong correlation between the angiographic circulation time and the cerebral blood flow during the balloon occlusion test. This result would make the balloon occlusion test safer and easier. This method enables us to estimate the tissue blood flow according to findings of the catheter angiogram and would be useful for the understanding pathophysiology of diseases in other tissues and organs.
Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage in one of poor prognostic factor. In this research, we revealed the usefulness of the real-time cerebral blood flow measurement for the prevention of the delayed cerebral ischemia.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Cerebral Blood Flow after Acute Bypass with Parent Artery Trapping in Patients with Ruptured Supraclinoid Internal Carotid Artery Aneurysms2015

    • Author(s)
      Endo H, Fujimura M, Shimizu H, Inoue T, Sato K, Niizuma K, Tominaga T.
    • Journal Title

      Journal of stroke and cerebrovascular diseases

      Volume: 24 Issue: 10 Pages: 2358-2368

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.06.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local vasogenic edema without cerebral hyperperfusion after direct revascularization surgery for moyamoya disease.2015

    • Author(s)
      Sakata H, Fujimura M, Mugikura S, Sato K, Tominaga T.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 24 Issue: 7 Pages: 179-184

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.03.050

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] クモ膜下出血後脳血流の時間的・空間的変化 3-D SRT softwareを用いたSPECT解析2015

    • Author(s)
      佐藤健一 清水宏明 井上敬 藤村幹 遠藤英徳 冨永悌二
    • Journal Title

      The Mt. Fuji Workshop on CVD

      Volume: 33 Pages: 98-102

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脳血管内治療における脳循環代謝研究2015

    • Author(s)
      佐藤健一
    • Journal Title

      脳循環代謝

      Volume: 26 Pages: 193-195

    • NAID

      130005093677

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery2015

    • Author(s)
      佐藤健一
    • Journal Title

      東北医学雑誌

      Volume: 127 Pages: 94-94

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery2014

    • Author(s)
      Kenichi Sato, Hiroaki Shimizu, Takashi Inoue, Miki Fujimura, Yasushi Matsumoto, Ryushi Kondo, Hidenori Endo, Yukihiko Sonoda, Teiji Tominaga
    • Journal Title

      Journal of Cerebral blood Flow Metabolism

      Volume: 34 Pages: 136-143

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] クモ膜下出血後急性期治療中の脳血流の時間的・空間的変化と臨床転帰との相関について- 3-D stereotactic surface projection imageを用いた検討2015

    • Author(s)
      佐藤健一 遠藤英徳 藤村幹 井上敬 清水宏明 冨永悌二
    • Organizer
      第27回日本脳循環代謝学会総会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Temporal and Spatial Change in Cerebral Blood Flow after Aneurysmal Subarachnoid Hemorrhage: Semi-Quantitative SPECT analysis2015

    • Author(s)
      Kenichi Sato, Hidenori Endo, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga
    • Organizer
      Vasospasm2015 13th international conference on neurovascular events after subarachnoid hemorrhage
    • Place of Presentation
      軽井沢プリンスホテルウエスト(長野県軽井沢町)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] クモ膜下出血後急性期治療中の脳血流の時間的・空間的変化と臨床転帰との相関について- 3-D stereotactic surface projection imageを用いた検討2015

    • Author(s)
      佐藤健一 遠藤英徳 藤村幹 井上敬 松本康史 清水宏明 冨永悌二
    • Organizer
      第25回東北脳SPECT研究会
    • Place of Presentation
      ホテルサンルートプラザ福島(福島県福島市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内頚動脈遮断時の脳血液循環と脳血流量の関係について

    • Author(s)
      佐藤健一 清水宏明 井上敬 藤村幹 遠藤英徳 冨永悌二
    • Organizer
      第23回東北脳SPECT研究会
    • Place of Presentation
      弘前市
    • Related Report
      2013 Research-status Report
  • [Presentation] 内頚動脈遮断時の脳血液循環と脳血流量の関係について

    • Author(s)
      佐藤健一 清水宏明 井上敬 藤村幹 遠藤英徳 冨永悌二
    • Organizer
      第25回日本脳循環代謝学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 内頚動脈遮断時の脳血液循環と脳血流量の関係について

    • Author(s)
      佐藤健一 松本康史 近藤竜史 遠藤英徳 冨永悌二
    • Organizer
      第29回NPO法人日本脳神経血管内治療学会学術総会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Research-status Report
  • [Presentation] 内頚動脈遮断時の脳血液循環と脳血流量の関係について

    • Author(s)
      佐藤健一 清水宏明 井上敬 藤村幹 遠藤英徳 冨永悌二
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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