| Project/Area Number |
25462205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSURUSHIMA Hideo 筑波大学, 医学医療系, 准教授 (50315470)
ITO Yoshiro 筑波大学, 医学医療系, 講師 (90733014)
中居 康展 筑波大学, 医学医療系, 講師 (40535069)
池田 剛 筑波大学, 医学医療系, 助教 (30709689)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | Vascular stenosis / Angioplasty / Liposome / Drug delivery / Selectin / carotid artery stenosis / angioplasty / drug delivery system / liposome / sialyl Lewis x / 頚動脈拡張損傷モデル |
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| Outline of Final Research Achievements |
Objective of our study is to build up a new method for management of post-angioplasty restenosis using liposomes, whose surface was decorated with sialyl Lewis X (SLX). Drug delivery is controlled with the affinity between SLX and E-selectin proteins, which are expressed on vessel walls after angioplasty and promote restenosis. Main theme of this task is visualization of E-selectin positive lesion on MRI. Gd-liposome SLX, which is liposome including gadolinium (Gd) with SLX decoration was used for E-selectin targeting. In vivo experiments confirmed accumulation of Gd matched with E-selectin positive lesions after angioplasty.
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