| Project/Area Number |
25462211
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
Nozaki Takao 浜松医科大学, 医学部附属病院, 助教 (10598494)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Kenji 浜松医科大学, 医学部, 準教授 (00235904)
尾内 康臣 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OUCHI Yasuomi 浜松医科大学, 医学部, 教授 (40436978)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | パーキンソン病 / 視床下核脳深部刺激療法 / 神経炎症反応 / ミクログリア / 神経保護効果 / 視床下核脳深部刺激術 |
|---|
| Outline of Final Research Achievements |
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in ameliorating the symotpms of Parkinson’s disease (PD). Recently, DBS is considered to have neuroprotective effect in PD. We are now focuing on the activation of microglia, namely, neuroinflammation. Previously, we had reported the increase of microglial activation in early PD. In this study, we have performed [11C]713DPA-PET, which is the tracer of microglia. The preliminary evaluation showed that the postoperative activations of microglia were relatively low compared with preoperative ones. We are currently analyzing the details of the data.
|
