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Development of regenerative medicine by oligodendrocyte and schwann precursor cells

Research Project

Project/Area Number 25462215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

Ohnishi Yuichiro  大阪大学, 医学(系)研究科(研究院), 助教 (00533811)

Co-Investigator(Kenkyū-buntansha) Yoshimine Toshiki (Shinzawa Koei)  大阪大学, 医学系研究科, 教授 (00201046)
Kishima Haruhiko  大阪大学, 医学系研究科, 講師 (10332743)
Iwatsuki Koichi  大阪大学, 医学系研究科, 准教授 (80346204)
新沢 康英  大阪大学, 医学(系)研究科(研究院), 助教 (70403186)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords嗅粘膜 / 神経幹細胞 / オリゴデンドロサイト前駆細胞 / GABAニューロン / オルファクトリースフィア / オリゴデンドロサイト / シュワン細胞 / ニューロン
Outline of Final Research Achievements

The olfactory epithelial layer contains multipotent horizontal base cells(HBCs) that differentiate into olfactory sensory neurons. We have identified that HBCs express oligodendrocyte precursor cell (OPC) and astrocyte markers.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Isolation of human adult olfactory sphere cells as a cell source of neural progenitors.2015

    • Author(s)
      Ohnishi Y1, Iwatsuki K2, Ishihara M2, Shikina T3, Shinzawa K4, Moriwaki T2, Ninomiya K2, Ohkawa T2, Umegaki M2, Kishima H2, Yoshimine T2.
    • Journal Title

      Stem Cell Research

      Volume: 15(1) Issue: 1 Pages: 23-29

    • DOI

      10.1016/j.scr.2015.04.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Olfactory sphere cells are a cell source for γ-aminobutyric acid-producing neurons.2015

    • Author(s)
      Ohnishi YI, Maruo T, Shinzawa K, Iwatsuki K, Moriwaki T, Oshino S, Kishima H, YoshimineT
    • Journal Title

      J Neurosci Res. 2

      Volume: 93 Issue: 8 Pages: 1293-1304

    • DOI

      10.1002/jnr.23585

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of intrapelvic sciatic nerve schwannoma presenting as piriformis syndrome.2014

    • Author(s)
      1. Ninomiya K, Iwatsuki K, Ohnishi Y, Moriwaki T, Yoshimine T.
    • Journal Title

      Journal of Neuroscinece and Behavioural Health.

      Volume: 6 Pages: 1-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adult olfactory sphere cells are a source of oligodendrocyte and Schwann cell progenitors.2013

    • Author(s)
      Ohnishi Y, Iwatsuki K et al.
    • Journal Title

      Stem Cell Research

      Volume: 11 Issue: 3 Pages: 1178-1190

    • DOI

      10.1016/j.scr.2013.08.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intradural extramedullary spinal ependymoma: a case report of malignant transformation occurring.2013

    • Author(s)
      7. Moriwaki T, Iwatsuki K, Ohnishi Y, Umegaki M, Ishihara M, Yoshimine T.
    • Journal Title

      Asian Spine Journal

      Volume: 7 Issue: 2 Pages: 139-42

    • DOI

      10.4184/asj.2013.7.2.139

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transplantation of Olfactory Mucosa as a Scaffold for Axonal Regeneration Following Spinal Cord Contusion in Rats.2013

    • Author(s)
      5. Iwatsuki K, Yoshimine T, Sankai Y, Umegaki M, Ohnishi Y, Ishihara M, Moriwaki T and Oda N.
    • Journal Title

      Neuroscience & Medicine.

      Volume: 4 Pages: 112-116

    • Related Report
      2013 Research-status Report
  • [Journal Article] Involuntary muscle spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia.2013

    • Author(s)
      4. Iwatsuki K, Yoshimine T, Sankai Y, Tajima F, Umegaki M, Ohnishi Y, Ishihara M, Ninomiya K and Moriwaki T.
    • Journal Title

      Journal of Biomedical Science and Engineering.

      Volume: 6 Pages: 908-916

    • Related Report
      2013 Research-status Report
  • [Presentation] 慢性期脊髄損傷に対する自己嗅粘膜移植術2013

    • Author(s)
      大西諭一郎
    • Organizer
      第67回近畿脊髄外科研究会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] オルファクトリースフィア細胞による中枢・末梢神経損傷治療の検討2013

    • Author(s)
      大西諭一郎
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] THE STEM CELL PROPETIES OF ADULT OLFACTORY HORIZONTAL BASAL CELLS2013

    • Author(s)
      Yu-ichiro Ohnishi
    • Organizer
      Glia meeting 2013
    • Place of Presentation
      Berlin
    • Related Report
      2013 Research-status Report
  • [Presentation] 脊髄円錐部グリオーマの一例2013

    • Author(s)
      大西諭一郎
    • Organizer
      第66回日本脳神経外科学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 当院での脊髄星細胞腫の治療2013

    • Author(s)
      大西諭一郎
    • Organizer
      第72回日本脳神経外科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] オルファクトリースフィア細胞による中枢・末梢神経損傷治療の検討2013

    • Author(s)
      大西諭一郎
    • Organizer
      第14回日本分子脳神経外科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Book] 脊椎脊髄ジャーナル2013

    • Author(s)
      大西諭一郎
    • Total Pages
      5
    • Publisher
      三輪書店
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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