Elucidation of a preventive strategy against diabetic dementia induced by blood-brain barrier disruption
| Project/Area Number |
25462220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
MOGI MASAKI 愛媛大学, 医学(系)研究科(研究院), 准教授 (20363236)
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Masatsugu 愛媛大学, 大学院医学系研究科, 教授 (40150338)
IWANAMI Jun 愛媛大学, 大学院医学系研究科, 助教 (90624792)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Kousei 愛媛大学, 大学院医学系研究科, 医員 (10598626)
TSUKUDA Kana 愛媛大学, 大学院医学系研究科, 研究員 (90647653)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / 認知機能 / 血液脳関門 / レニン・アンジオテンシン系 / AT2受容体 |
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| Outline of Final Research Achievements |
Type 2 diabetes mellitus has been highlighted as a major risk factor for cognitive decline associated with not only vascular dementia but also Alzheimer disease.We previously reported that BBB disruption was involved in T2DM-induced cognitive impairment.Here,we further investigated the relation between BBB disruption and diabetes. Results are shown below.
(1) In diabetic mice, KKAy, BBB disruption is occurred at first. Then, vascular dysfunction may be spread out to small vessel disease via time-course observation of KKAy brain (unpublished data). (2) Renin-angiotensin system may be involving BBB disruption via evaluation of BBB in human-renin and human-angiotensinogen overexpressed mice. (3) Angiotensin II type 2 receptor stimulation has a preventive effect on diabetic dementia and vascular dementia models using direct AT2 receptor stimulation with C21. Therefore, AT2 receptor stimulation may have a potential as new therapeutical approach for diabetic dementia.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.2015
Author(s)
Iwanami J, Mogi M, Tsukuda K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Shan BS, Kukida M, Horiuchi M.
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Journal Title
J Am Soc Hypertens
Volume: 9
Issue: 4
Pages: 250-256
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice.2014
Author(s)
Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Min LJ, Horiuchi M.
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Journal Title
Eur J Pharmacol
Volume: 724
Pages: 9-15
DOI
Related Report
Peer Reviewed
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[Presentation] 認知症と高血圧2015
Author(s)
茂木正樹
Organizer
第34回日本認知症学会学術集会
Place of Presentation
青森県青森市
Year and Date
2015-10-02
Related Report
Invited
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[Presentation] Possible Synergistic Effect of Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 with Memantine on Cognitive Impairment in Type 2 Diabetic Mouse
Author(s)
Masaki Mogi, Jun Iwanami, Hirotomo Nakaoka, Kana Tsukuda, Kousei Ohshima, Jing Fei, Xiaoli Wang, Toshiyuki Chisaka, Li-Juan Min and Masatsugu Horiuchi
Organizer
The Alzheimer's Association International Conference
Place of Presentation
Boston, MA, USA
Related Report
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