The basic research for the relationship of chronic inflammation and pathogenesis of cerebral aneurysm

• Project/Area Number: 25462224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: Kawano Takayuki 熊本大学, 生命科学研究部, 助教 (50448536)
• Co-Investigator(Kenkyū-buntansha): KURATSU Junichi 熊本大学, 大学院生命科学研究部, 教授 (20145296) ; OHMORI Yuki 熊本大学, 医学部附属病院, 特任助教 (60599116) ; MIYATA Keishi 熊本大学, 大学院生命科学研究部, 特任准教授 (50398228)
• Co-Investigator(Renkei-kenkyūsha): OIKE Yuichi 熊本大学, 大学院生命科学研究部, 教授 (90312321)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性炎症 / 動脈瘤 / angptl2 / 脳動脈瘤

Outline of Final Research Achievements

Our study shows the expression of macrophage in the cerebral aneurysm (CA) wall and suggests that is involved in CA pathogenesis. Chronic inflammation due to Angptl2 expression is thought to be the main cause of CA rupture. But our study does not suggests the correlation between Angptl2 expression and CA incidence in mouse aneurysm model.

Research Products

• [Journal Article] Prolonged Mean Transit Time Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Predicts Cerebrovascular Reserve Impairment in Patients with Moyamoya Disease (2016)
  • Author(s): Takayuki Kawano, Yuki Ohmori, Yasuyuki Kaku, Daisuke Muta, Ken Uekawa, Takashi Nakagawa, Toshihiro Amadatsu, Daiki Kasamo,Shinya Shiraishi,Mika Kitajima,Jun-ichi Kuratsu
  • Journal Title: Cerebrovascular disease Volume: 42 Issue: 1-2 Pages: 131-138
  • DOI: 10.1159/000445696
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Formation of a pseudoaneurysm in the chronic phase at the site of a ruptured dissecting anterior inferior cerebellar artery aneurysm (2015)
  • Author(s): Yushin Takemoto & Takayuki Kawano & Toru Nishi & Junichi Kuratsu
  • Journal Title: Acta Neurochir Volume: 157 Issue: 6 Pages: 1045-1047
  • DOI: 10.1007/s00701-015-2397-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Superficial temporal artery-to-middle cerebral artery bypass surgery for middle cerebral artery stenosis in a patient with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (2015)
  • Author(s): Muta D, Kawano T, Shinojima N, Kuratsu J
  • Journal Title: SpringerPlus Volume: 4 Issue: 1 Pages: 609-609
  • DOI: 10.1186/s40064-015-1407-7
  • Peer Reviewed / Open Access