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Water turnover in brain and ventricles in normal volunteers and patients with idiopathic NPH: dynamic PET study using H215O

Research Project

Project/Area Number 25462228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionNagoya City University

Principal Investigator

Mase Mitsuhito  名古屋市立大学, 医学(系)研究科(研究院), 教授 (60238920)

Co-Investigator(Kenkyū-buntansha) MORI Etsuro  東北大学, 医学(系)研究科, 教授 (30368477)
MIYATI Toshiaki  金沢大学, 保健学系, 教授 (80324086)
AOYAMA Kiminori  名古屋市立大学, 大学院医学研究科, 助教 (10597818)
Co-Investigator(Renkei-kenkyūsha) YAMADA Kazuo  名古屋市立大学, 大学院医学研究科, 教授 (90150341)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords髄液 / 産生吸収 / 水頭症 / H2O PET / ヒト / 水 / 髄液産成吸収 / ターンオーバー / 脳血流 / PET
Outline of Final Research Achievements

In order to clarify the origin and turnover of water molecules in CSF, dynamic PET study was performed using H215O. Normal volunteers (n=11) and patients with definite idiopathic normal pressure hydrocephalus (iNPH, n=2) were included. Dynamic PET data were obtained for 8 minutes after intravenous bolus injection of H215O (500MBq) in saline. Voxels of interest (VOI) were set in the internal carotid artery (ICA), cortical gray matter (GM), white matter (WM) lateral ventricle (LV) based on MR T1 (3D) images. The time and relative radio activity (RAA) curves of each VOI were analyzed.
The activities in the whole brain structures decreased gradually. On the contrary, the activity of LV increased gradually until the end of the measurement {27% of the whole brain parenchyma (GM+WM) activity at 8 minutes}. The RRA of LV in iNPH tended to be lower compared to the normal control.
This study showed very fast movement of water molecules from artery to brain parenchyma and ventricular CSF.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Presentation (4 results)

  • [Presentation] Dynamic PETによる頭蓋内の水のターンオーバーの解析:正常例とiNPH2016

    • Author(s)
      間瀬光人
    • Organizer
      第17回日本正常圧水頭症学会
    • Place of Presentation
      山形テルサ(山形県・山形市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamic PETによる頭蓋内の水のターンオーバーについて:正常例とiNPH2015

    • Author(s)
      間瀬光人
    • Organizer
      第8回日本水頭症脳脊髄液学会(シンポジウム4)
    • Place of Presentation
      順天堂大学(東京都・文京区)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamic PETによる脳実質および脳室内の水のターンオーバー解析2015

    • Author(s)
      間瀬光人
    • Organizer
      日本脳神経外科学会第74回学術総会
    • Place of Presentation
      ロイトン札幌,さっぽろ芸術文化の館,札幌市教育文化会館(北海道・札幌市)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamic PETによる頭蓋内の水ターンオーバーについて:正常例とiNPH2015

    • Author(s)
      間瀬光人
    • Organizer
      京都髄液フォーラム2015
    • Place of Presentation
      京都
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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