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Analysis of the neural network plasticity in the human basal ganglia disease using non-invasive molecular image

Research Project

Project/Area Number 25462229
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Sasajima Hiroyasu  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80196188)

Co-Investigator(Kenkyū-buntansha) OWADA Kei  京都府立医科大学, 医学研究科, 助教 (80332948)
MINEURA Katsuyoshi  京都府立医科大学, 医学研究科, 教授 (70134103)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords大脳基底核 / 神経画像診断学 / FDG- PET / Fluorodopa-PET / DAG-PET / 神経回路可塑性 / 運動関連領野 / 18F-fluorodeoxyglucose / 18F-fluorodopa / 11C-diacylglycerol / PET
Outline of Final Research Achievements

We analyzed a functional change of the neural network and neural plasticity in the human basal ganglia disease using PET from the viewpoint of signal transduction syatem. In stroke patients, because uptake of DAG was increased to prefrontal and parietal area for only subacute phase and attenuated after symptom improvement, it was estimated that this phenomenon reflected a plasticity mechanism. In two cases of bobble-head doll syndrome known as cranio-cervical dyskinesis, we reviewed that the presynaptic function of dopamine cells in the bilateral striatum was enhanced by fluorodopa-PET study. The suppression of output systems of basal ganglia caused by hyperfunction of the presynaptic dopaminergic cells may play an important role of the occurrence of bobble-head doll movement. The biochemical information obtained by the PET studies contributes to mechanism elucidation of the neural plasticity in the human basal ganglia disease.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Neurological symptoms in a patient with isolated adrenocorticotropin deficiency: case report and literature review.2016

    • Author(s)
      Goto Y, Tatsuzawa K, Aita K, Furuno Y, Kawabe T, Ohwada K, Sasajima H, Mineura K.
    • Journal Title

      BMC Endocrine Disorders

      Volume: 16 Issue: 1 Pages: 2-8

    • DOI

      10.1186/s12902-015-0082-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medical Comics as Tools to Aid in Obtaining Informed Consent for Stroke Care.2015

    • Author(s)
      Furuno Y, Sasajima H.
    • Journal Title

      Medicine

      Volume: 94 Issue: 26 Pages: 1-4

    • DOI

      10.1097/md.0000000000001077

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Strategies to prevent positioning-related complications associated with the lateral suboccipital approach.2014

    • Author(s)
      Furuno Y, Sasajima H, Goto Y, Taniyama I, Aita K, et al.
    • Journal Title

      J Neurol Surg B

      Volume: 75 Issue: 01 Pages: 35-40

    • DOI

      10.1055/s-0033-1353366

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児巨大脳腫瘍の手術.2015

    • Author(s)
      後藤幸大,笹島浩泰,他
    • Organizer
      第20回関西脳神経外科手術研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 前庭神経鞘腫の外科治療成績と治療戦略.2014

    • Author(s)
      笹島浩泰,立澤和徳,大和田敬,川邊拓也,会田和泰,古野優一,後藤幸大,峯浦一喜.
    • Organizer
      社団法人日本脳神経外科学会 第72 回学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Book] 脳外科医の欲する脳神経画像診断.戸村則昭(編).毛様細胞性星細胞腫.2015

    • Author(s)
      笹島浩泰.
    • Total Pages
      296
    • Publisher
      (株)映像情報メディカル,東京.
    • Related Report
      2015 Annual Research Report
  • [Book] 脳外科医の欲する脳神経画像診断.戸村則昭(編).神経鞘腫.2015

    • Author(s)
      笹島浩泰.
    • Total Pages
      296
    • Publisher
      (株)映像情報メディカル,東京.
    • Related Report
      2015 Annual Research Report
  • [Book] 脳外科医の欲する脳神経画像診断.戸村則昭(編).血管芽腫.2015

    • Author(s)
      笹島浩泰.
    • Total Pages
      296
    • Publisher
      (株)映像情報メディカル,東京.
    • Related Report
      2015 Annual Research Report
  • [Book] 脳外科医の欲する脳神経画像診断.戸村則昭(編).正常圧水頭症.2015

    • Author(s)
      後藤幸大,笹島浩泰.
    • Total Pages
      296
    • Publisher
      (株)映像情報メディカル,東京.
    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都府立医科大学 脳神経外科学教室ホームページ

    • URL

      http://www.f.kpu-m.ac.jp/k/neuro/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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