| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Suicide gene theraphy for malignant glioma using induced pluripotent stem cells(iPS cells) was studied. Mouse iPS cells indicated accumulation in a various glioma cell lines. The bystander effect with the glioma cells didn't give us the good effect, because cell contact is obstructed by speed of the iPS cell division and the colony formation.
When I made a mouse iPS cell differentiate into mesenchymal stem cell (MSC), and it was considered, good anti-tumor effect was admitted. The MELK gene which participates in colony formation was restrained in SiomycinA, but the effect was impartial. MELK genetic restraint could see reinforcement of the effect to cancer stem cell.
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